Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PRJNA127897
PROVIDER: E-GEOD-22809 | ExpressionAtlas | 2015-09-15
REPOSITORIES: ExpressionAtlas
Pedersen Jakob Madsen JM Fredsoe Jacob J Roedgaard Morten M Andreasen Lotte L Mundbjerg Kamilla K Kruhøffer Mogens M Brinch Marie M Schierup Mikkel Heide MH Bjergbaek Lotte L Andersen Anni Hangaard AH
PLoS genetics 20121220 12
To investigate the role of DNA topoisomerases in transcription, we have studied global gene expression in Saccharomyces cerevisiae cells deficient for topoisomerases I and II and performed single-gene analyses to support our findings. The genome-wide studies show a general transcriptional down-regulation upon lack of the enzymes, which correlates with gene activity but not gene length. Furthermore, our data reveal a distinct subclass of genes with a strong requirement for topoisomerases. These g ...[more]