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E-GEOD-23205

ABSTRACT: Transcription profiling of peripheral blood from patients with primary progressive multiple sclerosis to compare risk and protective PRF1 haplotypes

OTHER RELATED OMICS DATASETS IN: PRJNA131645

PROVIDER: E-GEOD-23205 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-23205-analysis-methods.tsv	Tabular
	E-GEOD-23205-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-23205-configuration.xml	Xml
	E-GEOD-23205-percentile-ranks.tsv	Tabular
	E-GEOD-23205.condensed-sdrf.tsv	Tabular

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Transcription profiling of peripheral blood from patients with primary progressive multiple sclerosis to compare risk and protective PRF1 haplotypes

Project description:A genetic study of the PRF1 gene has shown association of several polymorphisms with multiple sclerosis (MS). Haplotype analysis identified risk haplotypes strongly associated with male patients having the primary-progressive form of MS (PPMS). Gene expression microarrays were performed in 10 male PPMS patients carrying the risk (n=6) and protective haplotypes (n=4) in order to identify pathways associated with the risk haplotypes. Pathway analysis revealed overrepresentation of the cell killing gene ontology category among down-regulated genes in patients carrying risk haplotypes compared with patients carrying protective haplotypes. Number of samples analyzed: 10 Protective haplotype samples: UOM982, EMA1473, MMC-998, CDP1842 Risk haplotype samples: UUS1554, RAU1550, RPS1011, AGS1013, PFB1530, MGA1014

2010-07-28 | E-GEOD-23205 | biostudies-arrayexpress

Microarray expression analysis of PRF1 (perforin 1) haplotypes in patients with primary progressive multiple sclerosis

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