Transcriptomics,Multiomics

Dataset Information

5

MiRNA expressions in non-cancerous and cancerous human gastric tissues


ABSTRACT: We investigated the involvement of microRNAs (miRNAs) in gastric cancers. MiRNA expression was profiled from 40 cancerous and 40 non-cancerous tissues obtained from the National Cancer Centre, Singapore, and Singhealth Tissue Repository, Singapore. We identified 80 differentially expressed miRNAs in tumors compared with normal tissues. Among these miRNAs, we identified hsa-mir-486-5p (mir-486) as a significantly downregulated miRNA in GC. Subsequent functional characterization revealed that mir-486 playing a tumor suppressor role. We also observed frequent genomic deletion of mir-486 in 20-30% of GCs. To our knowledge, mir-486 represents one of the first tumor suppressor miRNAs in GC inactivated through genomic deletion. MiRNA expression was profiled on Agilent Human miRNA Microarrays (V2) representing 723 human and 76 human viral miRNAs in 40 normal and 40 cancerous gastric tissues.

REANALYSIS of: E-GEOD-23739

ORGANISM(S): Homo sapiens  

PROVIDER: E-GEOD-23739 | ExpressionAtlas | 2015-07-29

REPOSITORIES: ExpressionAtlas

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Publications

Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer.

Oh Hue-Kian HK   Tan Angie Lay-Keng AL   Das Kakoli K   Ooi Chia-Huey CH   Deng Nian-Tao NT   Tan Iain Beehuat IB   Beillard Emmanuel E   Lee Julian J   Ramnarayanan Kalpana K   Rha Sun-Young SY   Palanisamy Nallasivam N   Voorhoeve P Mathijs PM   Tan Patrick P  

Clinical cancer research : an official journal of the American Association for Cancer Research 20110317 9


PURPOSE: MicroRNAs (miRNA) play pivotal oncogenic and tumor-suppressor roles in several human cancers. We sought to discover novel tumor-suppressor miRNAs in gastric cancer (GC). EXPERIMENTAL DESIGN: Using Agilent miRNA microarrays, we compared miRNA expression profiles of 40 primary gastric tumors and 40 gastric normal tissues, identifying miRNAs significantly downregulated in gastric tumors. RESULTS: Among the top 80 miRNAs differentially expressed between gastric tumors and normals (false dis  ...[more]

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