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E-GEOD-24068

ABSTRACT: Transcription profiling by array of human bone engrafted with myeloma cell line Hg, in SCID mice treated with parathyroid hormone or saline

PROVIDER: E-GEOD-24068 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-24068-analysis-methods.tsv	Tabular
	E-GEOD-24068-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-24068-configuration.xml	Xml
	E-GEOD-24068-percentile-ranks.tsv	Tabular
	E-GEOD-24068.condensed-sdrf.tsv	Tabular

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Gene expression from SCID-hu mice treated with saline (control) or intermittent PTH

Project description:The data present global gene expression profile of whole human bones, implanted in SCID mice (SCID-hu model), then engrafted with the myeloma cell line, Hg, and treated with saline or PTH for 4 weeks. SCID-hu mice were prepared by subcutaneous implantation of human bone in SCID mice. The human myeloma cell line, Hg was injected directly into the implanted bone in SCID-hum mice. Upon establishment of myeloma growth as determined by measurement of circulating human immunoglobulins in SCID-hu mice sera, the mice were treated with saline or intermittent PTH (parathyroid hormone, 80 ug/kg/day) for 4 weeks. At the end of the experiment, the human bones from SCID-hu mice were snap frozen in liquid nitrogen. RNA extracted from these bones was subjected to global gene expression profile using Affymetrix U133-Plus microarray.

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