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E-GEOD-29908

ABSTRACT: Expression data from peripheral blood mononuclear cell in patients with type 1 diabetes before and after peripheral stem cell transplantation

OTHER RELATED OMICS DATASETS IN: PRJNA140819

PROVIDER: E-GEOD-29908 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-29908-analysis-methods.tsv	Tabular
	E-GEOD-29908-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-29908-configuration.xml	Xml
	E-GEOD-29908-percentile-ranks.tsv	Tabular
	E-GEOD-29908.condensed-sdrf.tsv	Tabular

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Expression data from peripheral blood mononuclear cell in patients with type 1 diabetes before and after peripheral stem cell transplantation

Project description:Autologous nonmyeloablative hematopoietic stem cell transplantation (AHST) was the first therapeutic approaches that can improve beta cell function in type 1 diabetic (T1D) patients. This study was designed to investigate the potential mechanisms involved.We applied AHST to nine T1D patients diagnosed within six months and analyzed the acute response in peripheral blood genomic expression profiling at the six-month follow-up. Peripheral blood mononuclear of newly diagnosed type1 diabetes patients at diagnosis and at six months post-transplantation by autologous peripheral stem cell were purified by LymphoprepTm gradient purification according to the manufacturer's instructions (Axis-Shield PoC AS, Oslo, Norway) for futher microarray analysis.

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