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E-GEOD-31782

ABSTRACT: Knock-down and Over-expression of JMJD6 in MCF-7 and/or MDA-MB231

OTHER RELATED OMICS DATASETS IN: PRJNA145293

PROVIDER: E-GEOD-31782 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-31782-analysis-methods.tsv	Tabular
	E-GEOD-31782-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-31782-configuration.xml	Xml
	E-GEOD-31782-percentile-ranks.tsv	Tabular
	E-GEOD-31782.condensed-sdrf.tsv	Tabular

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Knock-down and Over-expression of JMJD6 in MCF-7 and/or MDA-MB231

Project description:By survival analysis of breast cancer patients, JMJD6 was found to be significantly associated with poor prognosis. Over-expression and knock-down of JMJD6 in breast cancer cell lines suggested a role in proliferation. In order to study the transcriptional events that occur following JMJD6 expression changes, siRNA-mediated knock-down of JMJD6 was performed in MCF-7 and MDA-MB231 and stable over-expression of JMJD6 was performed in MCF-7. There are 2 different siRNA-mediated knock-downs of JMJD6 with 2 biological replicates in MCF-7 and MDA-MB231; 3 clones of JMJD6 over-expression with 3 biological replicates in MCF-7. The control for the knock-downs is scrambled siRNA-treated MCF-7 and MDA-MB231 and the control for JMJD6 over-expression is empty vector over-expression in MCF-7.

2012-05-09 | E-GEOD-31782 | biostudies-arrayexpress

Knock-down and Over-expression of JMJD6 in MCF-7 and/or MDA-MB231

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