Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-34331

ABSTRACT: Transcription profiling by array of human breast cancer MCF-7 cells treated with novel compound F05 which promotes neurite growth on inhibitory substrates

OTHER RELATED OMICS DATASETS IN: PRJNA151493

PROVIDER: E-GEOD-34331 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-34331-analysis-methods.tsv	Tabular
	E-GEOD-34331-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-34331-configuration.xml	Xml
	E-GEOD-34331-percentile-ranks.tsv	Tabular
	E-GEOD-34331.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 62

Similar Datasets

E-MTAB-339

Project description:Transcription profiling by array of human breast cancer MCF-7 cells treated with 17-AAG

2025-01-23 | E-MTAB-339 | ExpressionAtlas

E-GEOD-11791

Project description:Transcription profiling by array of human MCF-7 breast cancer cells

2025-01-16 | E-GEOD-11791 | ExpressionAtlas

A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates.

Project description:Injury to the central nervous system (CNS) may result in lifelong loss of function due, in part, to the regenerative failure of CNS neurons. Major barriers to regeneration faced by injured CNS neurons include inhibitory proteins derived from myelin and the astroglial scar. Previously, we described the identification of a novel compound, F05, which promotes neurite growth from neurons challenged with inhibitory substrates in vitro, and promotes axonal regeneration in vivo (Usher et al., 2010). To identify additional regeneration promoting compounds, we used the microarray derived gene expression signature of F05 to query the Broad Institute Connectivity Map, a database of gene expression profiles for cells treated with >1,300 compounds. Unexpectedly, F05 induced changes in gene expression remarkably similar to those seen with a group of piperazine phenothiazine antipsychotics (PhAPs). We found that, in contrast to antipsychotics of other structural classes, PhAPs were able to promote neurite growth of CNS neurons cultured on two different glial-derived inhibitory substrates, but did not promote growth on a permissive substrate. Pharmacological studies suggest that the ability of PhAPs to promote growth depends on antagonism of calmodulin signaling, but not on dopamine receptor antagonism. Our findings shed light on mechanisms underlying neurite-inhibitory signaling, and suggest a potential pathway for development of novel treatments for CNS injury. 3 Biological Replicates of Vehicle Treated (0.05% DMSO) + 3 Biological Replicates of F05 Treated (5 μM)

2012-04-29 | E-GEOD-34331 | biostudies-arrayexpress

E-GEOD-22533

Project description:Transcription profiling by array of human breast cancer cell lines treated with fulvestrant

2025-01-24 | E-GEOD-22533 | ExpressionAtlas

A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates.

2012-04-30 | GSE34331 | GEO

E-GEOD-18912

Project description:Expression profiling of breast cancer cell lines MCF-7 and MCF-7R4

2025-01-24 | E-GEOD-18912 | ExpressionAtlas

E-GEOD-11352

Project description:Transcription profiling by array time series of human MCF7 breast cancer cells treated with estradiol

2025-01-16 | E-GEOD-11352 | ExpressionAtlas

E-GEOD-10879

Project description:Transcription profiling by array of human hormone-responsive MCF-7 cells versus estrogen-deprived breast cancer cells

2025-01-16 | E-GEOD-10879 | ExpressionAtlas

E-TABM-1118

Project description:Transcrption profiling by array of human breast cancer cells treated with LPS-Stimulated macrophage conditioned media

2025-01-16 | E-TABM-1118 | ExpressionAtlas

E-GEOD-7515

Project description:Transcription profiling by array of human breast cancer mammospheres and breast tumors

2025-01-24 | E-GEOD-7515 | ExpressionAtlas

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data