Project description:Familial dysautonomia (FD) results from mutation in IKBKAP/ELP1, a gene encoding the scaffolding protein for the Elongator complex. This highly conserved complex is required for the methoxy-carbonyl-methyl (mcm5) modification of uridines located in the wobble position of tRNA molecules (U34). In FD, the peripheral nervous system is particularly devastated by loss of IKBKAP. Here we investigate protein expression within the dorsal root ganglia (DRG) of a mouse model of FD. In this model, Ikbkap is selectively deleted in the neural crest lineage using a Wnt1-Cre transgene and floxed Ikbkap. DRG were collected and pooled from seven Ikbkap conditional knockout (Wnt1-Cre;IkbkapLoxP/LoxP) and seven control E17.5 mice and analyzed via UHPLC-MS/MS.

| MSV000081568 | MassIVE

Saccharomyces cerevisiae

Project description:Expression profile of nab2-1 mutant

| PRJNA135115 | ENA

Gene expression profile of zebrafish synpo2 mutant

Project description:Gene expression profile of zebrafish synpo2 mutant

| PRJNA630990 | ENA

Gene expression profile of zebrafish tet2 mutant

Project description:Gene expression profile of zebrafish tet2 mutant

| PRJNA562257 | ENA