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E-GEOD-40840

ABSTRACT: SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

PROVIDER: E-GEOD-40840 | ExpressionAtlas | 2020-03-31

REPOSITORIES: ExpressionAtlas

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SM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts

Project description:Comparing the host response of C57BL/6J mice to KEPI (ppp1r14c) knockouts in the same strain of mice. Groups of 10-week-old C57BL/6 mice or KEPI (ppp1r14c) knockout mice were infected with SARS MA15 at a dose of 10^5 PFU or mock infected. Mice were euthanized on days 4 and 7 post-infection to measure virus load and isolate samples for measurement of virus load, lung pathology, transcriptional analysis and proteomics analysis. Mock-infected animals were also harvested at each time point. Mice were weighed every 24 hours to measure general disease progression and any mouse approaching 30% weight loss was euthanized.

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SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

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Project description:SM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts

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Project description:SM015 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1a/1b knockouts

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E-GEOD-40827

Project description:SM020 - Infection with SARS MA15 of C57BL/6J mice and KEPI (ppp1r14c) knockouts

2020-03-31 | E-GEOD-40827 | ExpressionAtlas

SM001: SARS CoV MA15 infection of C57Bl/6 mouse model – Data from 4 viral doses at 1, 2, 4 and 7 days post infection.

Project description:Purpose of experiment was to perform transcriptomic analysis on C57Bl/6 mice infected with different doses of SARS CoV MA15 at 4 different days post infection.

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Project description:SM019 - Infection with SARS MA15 of C57BL/6J mice and Tnfrsf1b knockout mice

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