Project description:We have found that innate immune cells (monocytes/macrophages) are compromised in malignant glioma, and we have determined that vitamin B3 (niacin) reactivates and/or reprograms monocytes/macrophages to inhibit glioma growth, particularly by suppressing the growth of brain tumor initiating cells (BTICs). To this end, we sought to obtain insights into the mechanisms by which niacin regulates monocyte/macrophage activity to alter glioma growth. Analysis of the microarray data identified several genes that were differentially altered in niacin-treated monocytes that could regulate BTIC growth. The study has identified a mechanistic basis for the regulation of glioma growth with niacin treatment.

2017-09-05 | GSE103381 | GEO

Khajanchi2019 - Stability Analysis of a Mathematical Model forGlioma-Immune Interaction under OptimalTherapy

Project description:Stability Analysis of a Mathematical Model for Glioma-Immune Interaction under Optimal Therapy Subhas Khajanchi Abstract We investigate a mathematical model using a system of coupled ordinary differential equations, which describes the interplay of malignant glioma cells, macrophages, glioma specific CD8+T cells and the immunotherapeutic drug Adoptive Cellular Immunotherapy (ACI). To better understand under what circumstances the glioma cells can be eliminated, we employ the theory of optimal control. We investigate the dynamics of the system by observing biologically feasible equilibrium points and their stability analysis before administration of the external therapy ACI. We solve an optimal control problem with an objective functional which minimizes the glioma cell burden as well as the side effects of the treatment. We characterize our optimal control in terms of the solutions to the optimality system, in which the state system coupled with the adjoint system. Our model simulation demonstrates that the strength of treatment u1(t) plays an important role to eliminate the glioma cells. Finally, we derive an optimal treatment strategy and then solve it numerically. Keywords: malignant gliomas; stability analysis; optimal control; adoptive cellular immunotherapy

2020-01-03 | BIOMD0000000891 | BioModels

Affymetrix SNP array data for Pediatric malignant glioma samples

Project description:Data includes all available Affymetrix SNP data from a cohort of Pediatric malignant glioma samples, isolated from Formalin-fixed Paraffin embedded tissue. No clinical data is available. Copy number analysis of Affymetrix 250K Sty SNP arrays was performed for 28 pediatric malignant gliomas. The VN algorithm was used to generate the reference signal based on 48 Mapping 500k HapMap Trio Dataset template.

2011-11-23 | E-GEOD-25589 | biostudies-arrayexpress

Regulatory Landscape and Clinical Implication of MBD3 in Human Malignant Glioma [MBD3 knockdown in SF767]

Project description:A comprehensive study is conducted to inspect the role and function of methyl-CpG-binding domain protein 3 (MBD3) in human malignant glioma, as well as to test its potential as a novel prognostic biomarker. Using whole-genome microarray for transcriptome, the MBD3-mediated epigenetic regulation in glioma was profiled.

2016-11-08 | GSE79877 | GEO

Regulatory Landscape and Clinical Implication of MBD3 in Human Malignant Glioma [low-grade glioma and glioblastoma screening]

2016-11-08 | GSE79876 | GEO

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