Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-50467

ABSTRACT: Effect of SRSF2 over-expression in a human lung carcinoma cell line

OTHER RELATED OMICS DATASETS IN: PRJNA217533

PROVIDER: E-GEOD-50467 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-50467-analysis-methods.tsv	Tabular
	E-GEOD-50467-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-50467-configuration.xml	Xml
	E-GEOD-50467-percentile-ranks.tsv	Tabular
	E-GEOD-50467.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 53

Similar Datasets

iAR22_SARS-CoV-2_scH1299 - cell-type specific constraint-based metabolic models of human H1299 cells with SARS-CoV-2 infection

Project description:A collection of cell-type specific constraint-based metabolic models of human H1299 cells (human non-small cell lung carcinoma cell line) infected with SARS-CoV-2 based that were generated based on gene-expression data.

2025-04-07 | MODEL2311070004 | BioModels

Homo sapiens

Project description:Effect of SRSF2 over-expression in a human lung carcinoma cell line

| PRJNA217533 | ENA

iAR22_SARS-CoV-2_Calu3 - A collection of cell-type specific constraint-based metabolic models of human Calu-3 cells infected with SARS-CoV-2

Project description:A collection of cell-type specific constraint-based metabolic models of Calu-3 cells (a human lung epithelial cancer cell line) infected with SARS-CoV-2 based that were generated based on gene-expression data.

2025-04-14 | MODEL2311070005 | BioModels

RNAi knock down of FAM33A in a human lung carcinoma cell line

Project description:The effect of endogenous FAM33A knockdown by RNAi on the gene expression profile of a lung carcinoma cell line

2008-10-30 | E-MEXP-875 | biostudies-arrayexpress

Effect of over expression of MED13 IDR in human osteosarcoma U2OS cell line

Project description:Effect of over expression of MED13 IDR in human osteosarcoma U2OS cell line

| PRJNA1054158 | ENA

cMyc and Max ChIP-seq analysis in small cell lung carcinoma cells

Project description:cMyc and Max ChIP-seq analysis in a high MYC expressing small cell lung carcinoma cell line (H2171) and a low MYC expressing small cell lung carcinoma cell line (H128).

2012-09-25 | GSE41105 | GEO

SCLC LCNEC FFPE LMD

Project description:Small-cell lung carcinoma (SCLC) and large-cell neuroendocrine lung carcinoma (LCNEC) are high-grade lung neuroendocrine tumors (NET). However, comparative protein expression within SCLC and LCNEC remains unclear. Here, protein expression profiles were obtained via mass spectrometry-based proteomic analysis.

2019-05-14 | PXD013583 | JPOST Repository

USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma

Project description:Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient 5-year survival rate is less than 5%. The ubiquitin specific protease 28 (USP28) has been implicated in tumorigenesis through its stabilization of the oncoprotein c-MYC. Here, we show that genetic inactivation of USP28 induced regression of established murine LSCC lung tumors. We developed small molecule USP28 inhibitors that inhibit USP28 activity in the low nanomole range. While displaying considerable activity against the closest homologue USP25, these inhibitors showed a high degree of selectivity over other deubiquitinases. USP28 inhibitor treatment resulted in a dramatic decrease in c-Myc proteins levels and consequently induced substantial regression of autochthonous murine LSCC tumors and human LSCC xenografts, thereby phenocopying the effect observed by genetic deletion. Thus, USP28 may represent a promising therapeutic target for the treatment of squamous cell lung carcinoma.

2024-07-30 | PXD023339 | Pride

Homo sapiens

Project description:Expression data in human esophageal squamous carcinoma cell line KYSE150 with LOXL2 delta 72 over-expression

| PRJNA232544 | ENA

Homo sapiens

Project description:Human lung squamous cell carcinoma expression profiling

| PRJNA118343 | ENA