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Omics score: 0

E-GEOD-52511

ABSTRACT: Comparison of gene expression in wild-type Drosophila testes with tbrd-1 mutant testes

OTHER RELATED OMICS DATASETS IN: PRJNA229150

PROVIDER: E-GEOD-52511 | ExpressionAtlas | 2015-07-29

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-52511-analysis-methods.tsv	Tabular
	E-GEOD-52511-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-52511-configuration.xml	Xml
	E-GEOD-52511-percentile-ranks.tsv	Tabular
	E-GEOD-52511.condensed-sdrf.tsv	Tabular

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Project description:Comparison of gene expression in wild-type Drosophila testes with tbrd-1 mutant testes

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Comparison of gene expression in wild-type Drosophila testes with tbrd-1 mutant testes

Project description:Gene expression is tightly linked to histone acetylation on lysine residues that can be recognized by bromodomains. The testis-specific bromodomain protein tBRD-1 is essential for male fertility and might act as a co-factor of testis-specifc TAFs. Here, we perform microarray analyses and demonstrate that tBRD-1 selectively controls gene expression in male germ cells Testes were dissected from 0-2 day old Drosophila males. The wild-type control sample was w1118. The tbrd-1 mutant is described in Leser et al., 2012 (Leser K, Awe S, Barckmann B, Renkawitz-Pohl R, Rathke C. 2012. The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility. Biology Open 1: 597-606)

2014-08-08 | E-GEOD-52511 | biostudies-arrayexpress

E-GEOD-39298

Project description:Comparison of transcriptome profile between wild-type and Epi-df mutant plants

2015-12-01 | E-GEOD-39298 | ExpressionAtlas

RNA-seq of Drosophila melanogaster testis with or without tbrd-1 knock out or tplus3a/b knock out

Project description:Many protein complexes are involved in gene regulation during Drosophila spermatogenesis. tplus3a and tplus3b code for Plus3 domain proteins and are enriched in spermatocytes. Male flies ∆tplus3a/b carrying deletions of both genes in trans to deficiency Df(2L)BSC151 show severely reduced fertility. tbrd-1 is known to regulate hundreds of genes during spermatogenesis in cooperation with tTAFs. To gain more insight into the regulatory mechanisms during spermatogenesis we used RNA from testes of ∆tplus3a/b/Df(2L)BSC151 and tbrd-11 mutant flies for RNAseq in comparison to w1118 wild-typic control. RNA was isolated with Trizol from 200 Testes dissected from w1118, homozygous tbrd-11 mutants or ∆tplus3a/b/Df(2L)BSC151. After DNAse I digestion RNA was purified and RNAseq was performed in three replicates. Genotype Description: w1118: wild-typic control tbrd-11: homozygous tbrd-11 mutants (knock-out through P{EPgy2}tbrd-11, as described in Leser et al., 2012) ∆tplus3a/b/Df(2L)BSC151: CRISPR/Cas9 deletion mutants, representing knock-out of both tplus3 and tplus3b. Male flies y1cho2v1;∆tplus3a/b/CyO were crossed with virgin females w1118;Df(2L)BSC151/CyO. Male offspring with w1118;∆tplus3a/b/Df(2L)BSC151 were used for RNAseq.

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Project description:Gene expression data from Arabidopsis wild-type and pop2-1 mutant flowers

2014-07-03 | E-GEOD-21945 | ExpressionAtlas