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E-GEOD-55098

ABSTRACT: Expression data from peripheral blood mononuclear cell in patients with type 1 diabetes compared with normal controls

PROVIDER: E-GEOD-55098 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-GEOD-55098-analysis-methods.tsv	Tabular
	E-GEOD-55098-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-55098-configuration.xml	Xml
	E-GEOD-55098-percentile-ranks.tsv	Tabular
	E-GEOD-55098.condensed-sdrf.tsv	Tabular

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Project description:Genome-Scale draft model for Human Peripheral Blood Mononuclear Cells (PBMCs). A GEM for PBMCs was developed by applying the INIT algorithm on Human Metabolic Reconstruction (HMR 2.0) as a template model. GEMs were contextualised/ constrained for different conditions using expression datasets. The gene/transcript expression data obtained from PBMCs of Type 1 Diabetes progressors, non-progressors, and healthy controls were employed to score each reaction of HMR 2.0. For further detail please refer to Electronic Supplementary Information of Sen et.al, Metabolic alterations in immune cells associate with progression to type 1 diabetes, Diabetologia, 15/01/2020, (https://doi.org/10.1007/s00125-020-05107-6).

2020-03-11 | MODEL1905270001 | BioModels

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