Browse
Submit Data
Databases
API
Help

Dataset Information

20 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-55859

ABSTRACT: Gene expression profile of TRAIL-sensitive and -resistant H460 cells

PROVIDER: E-GEOD-55859 | ExpressionAtlas | 2014-09-08

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Similar Datasets

Homo sapiens

Project description:Gene expression profile of TRAIL-sensitive and -resistant H460 cells

| PRJNA241163 | ENA

Project description:Gene expression profile of resistant- and sensitive-Aedes albopictus

| PRJNA756868 | ENA

Homo sapiens

Project description:MicroRNA expression profile in TRAIL-sensitive and -resistant H460 cells

| PRJNA241076 | ENA

Gene expression profile of K562 human leukemia cell line after imatinib treatement

Project description:K562 cells when grown with erythropeitin do not respond to Imatinib. Here we are comparing the gene expression profile from imatinib resistant and sensitive cells.

2017-03-20 | GSE75055 | GEO

E-GEOD-28784

Project description:Gene expression data of sensitive, Docetaxel resistant and Paclitaxel resistant MDA-MB-231 Cells

2015-08-12 | E-GEOD-28784 | ExpressionAtlas

Landscape of somatic mutations and DNA copy number alterations and transcriptomic profiling identifies metabolic reprogramming as a hallmark of ibrutinib resistance

Project description:Whole-exome sequencing (WES) was conducted on the clinical specimens of 14 cases that had sufficient isolated tumor DNA, including 7 ibrutinib-sensitive cases and 7 ibrutinib-resistant cases. Whole transcriptome sequencing (RNA-seq) was performed on clinical specimens isolated from 14 ibrutinib-sensitive and 7 ibrutinib-resistant cases. Unsupervised hierarchical clustering of MCL tumors using RNA-seq gene expression data showed a response-specific gene expression signature.

| EGAS00001003418 | EGA

Gene expression in radio-sensitive or -resistant breast cancer cells

Project description:Gene expression in radio-sensitive or -resistant breast cancer cells

| PRJNA664100 | ENA

Single Cell Analysis Reveals NUPR1 Promotes Docetaxel Resistance in Prostate Cancer

Project description:The majority of prostate cancer (PCa) patients treated with docetaxel develop resistance to it. In order to better understand the mechanism behind the acquisition of resistance, we conducted single cell total RNA sequencing (sctotal RNA-seq) of docetaxel sensitive and resistant variants of DU145 and PC3 PCa cell lines. Overall, sensitive and resistant cells clustered separately. However, for both cell lines we identified rare sensitive cells that clustered with the resistant cells indicating resistant cells pre-exist in the sensitive population. Differential gene expression analysis between resistant and sensitive cells revealed 182 differentially expressed genes common to both PCa cell lines. A subset of these genes gave a gene expression profile in the resistant-like sensitive cells similar to the resistant cells. Exploration for functional gene pathways identified 218 common pathways between the two cell lines. Protein ubiquitination was the most differentially regulated pathway and was enriched in the resistant cells. Transcriptional regulator analysis identified potential 321 regulators across both cell lines. One of the top regulators identified was nuclear protein 1 (NUPR1). In contrast to the single cell analysis, bulk analysis of the cells did not reveal NUPR1 as a promising candidate. Knockdown and overexpression of NUPR1 in the PCa cells demonstrated that NUPR1 confers docetaxel resistance in both cell lines. Collectively, these data demonstrate the utility of sctotal RNA-seq to identify regulators of drug resistance. Furthermore, NUPR1 was identified as a mediator of PCa drug resistance, which provides the rationale to explore NUPR1 and its target genes to for reversal of docetaxel resistance.

2020-09-01 | GSE140440 | GEO

Gene expression profile of TRAIL-sensitive and -resistant H460 cells

Project description:We generated H460 cells with acquired TRAIL resistance by exposing the parental sentisitve cells to subtoxic concentrations of TRAIL for 6 months. Then we compared the gene expression profile of the sensitive versus the resistant cells. We generated acquired TRAIL-resistant H460 cells from the sentisitve cells by treating subtoxic range of TRAIL for 6 month. And we tried to compare the expressional profile of the genes between two cell types to isolate genes regulating acquired TRAIL-resistance

2014-09-01 | GSE55859 | GEO

Drosophila melanogaster

Project description:xray induced expression profile change in sensitive vs resistant embryos

| PRJNA87059 | ENA