Genomics

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Transcriptional profiling of mouse urinary bladder with cyclophosphamide-induced cystitis


ABSTRACT: To analyze the gene expression of non-bacterial bladdder inflammation, mouse cyclophosphamide(CYP)-induced model of cystitis was adapted. Forty-eight hour after CYP or vehicle treatment, total RNA was extracted from CYP-treated group (CYP150) and control group (CYP0). We used microarrays to detail the gene expression underlying bladder inflammation. Five-week-old female Balbc/A mice were injected intraperitoneally with 150mg/kg body weight of CYP diluted in 15ml/kg body weight of saline. Mice injected with saline alone served as controls. Treated mice were killed 48 hours after administaration and the whole bladders harvested. Total RNA was extracted and microarray analysis was performed.

REANALYSIS of: E-GEOD-55986

OTHER RELATED OMICS DATASETS IN: PRJNA241947

ORGANISM(S): Mus musculus  

PROVIDER: E-GEOD-55986 | ExpressionAtlas | 2015-07-29

REPOSITORIES: ExpressionAtlas

Dataset's files

Source:
Action DRS
E-GEOD-55986-analysis-methods.tsv Tabular
E-GEOD-55986-atlasExperimentSummary.Rdata Rdata
E-GEOD-55986-configuration.xml Xml
E-GEOD-55986-percentile-ranks.tsv Tabular
E-GEOD-55986.condensed-sdrf.tsv Tabular
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Publications

Altered detrusor gap junction communications induce storage symptoms in bladder inflammation: a mouse cyclophosphamide-induced model of cystitis.

Okinami Takeshi T   Imamura Masaaki M   Nishikawa Nobuyuki N   Negoro Hiromitsu H   Sugino Yoshio Y   Yoshimura Koji K   Kanematsu Akihiro A   Hashitani Hikaru H   Ogawa Osamu O  

PloS one 20140806 8


Lower urinary tract symptoms (LUTS) include storage, voiding and post-micturition symptoms, featuring many urological diseases. Storage symptoms are the most frequent among these and associated with overactive bladder and non-bacterial bladder inflammation such as interstitial cystitis/bladder pain syndrome (IC/BPS). Gap junction, a key regulator of hyperactive conditions in the bladder, has been reported to be involved in pathological bladder inflammation. Here we report involvement of gap junc  ...[more]

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