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E-GEOD-59284

ABSTRACT: SM5-1-conjugated gold nanoparticles for antibody therapy in hepatocellular carcinoma

PROVIDER: E-GEOD-59284 | ExpressionAtlas | 2025-01-24

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-GEOD-59284-analysis-methods.tsv	Tabular
	E-GEOD-59284-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-59284-configuration.xml	Xml
	E-GEOD-59284-percentile-ranks.tsv	Tabular
	E-GEOD-59284.condensed-sdrf.tsv	Tabular

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Homo sapiens

Project description:SM5-1-conjugated gold nanoparticles for antibody therapy in hepatocellular carcinoma

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SM5-1-conjugated gold nanoparticles for antibody therapy in hepatocellular carcinoma

Project description:As a humanized mouse antibody, SM5-1 can target a membrane protein of about 230kDa over-expressed in hepatocellular carcinoma (HCC), melanoma and breast cancer and it has been found to inhibit the progress of tumor cells. In this study, SM5-1 conjugated gold nanoparticles were prepared to study the antitumor efficacy in the treatment of HCC-LM3-fLuc tumor. The results showed that AU-SM5-1 could inhibit HCC-LM3 hepatocellular carcinoma cell proliferation up to 71.26% at the concentration of 0.5mg/ml contrast with SM5-1 and gold nanoparticles. In order to address the mechanism of the antiproliferative effects of AU-SM5-1, we examined the gene expression in HCC-LM3-fLuc tumor cells based on gene-chip screening.

2014-07-11 | GSE59284 | GEO

SM5-1-conjugated gold nanoparticles for antibody therapy in hepatocellular carcinoma

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Project description:Toxicogenomic responses of C. elegans to gold nanoparticles

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Project description:Transcriptome sequencing of human hepatocellular carcinoma

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Project description:Combination therapy with anti PD-1 and β -catenin siRNA delivered using biological nanoparticles provide an effective strategy for the treatment of Hepatocellular carcinoma.

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Project description:Transcriptomic characterization of Hepatocellular Carcinoma with CTNNB1 mutation

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