Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-59928

ABSTRACT: Expression data from 24 hours of Sox17 overexpression in pancreatic islets of a 16-week old mice

OTHER RELATED OMICS DATASETS IN: PRJNA257072

PROVIDER: E-GEOD-59928 | ExpressionAtlas | 2015-07-29

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-59928-analysis-methods.tsv	Tabular
	E-GEOD-59928-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-59928-configuration.xml	Xml
	E-GEOD-59928-percentile-ranks.tsv	Tabular
	E-GEOD-59928.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 52

Similar Datasets

Mus musculus

Project description:Expression data from 24 hours of Sox17 overexpression in pancreatic islets of a 16-week old mice

| PRJNA257072 | ENA

Expression data from 24 hours of Sox17 overexpression in pancreatic islets of a 16-week old mice

Project description:Secretion of insulin by pancreatic β cells in response to glucose is central for glucose homeostasis, and dysregulation of this process is a hallmark of the early stages of diabetes. We utilized a tetracycline-inducible approach to investigate the immediate impact of a pulse of Sox17 expression on the insulin secretory pathway. Sox17 gain-of-function animals (Sox17-GOF) were generated using an Ins2-rtTA mouse line and a line in which Sox17 expression is regulated by the tetracycline transactivator (tetO-Sox17). Administering doxycycline to 16-week old mice resulted in Sox17 overexpression in mature β cells in the islets. In order to identify the molecular basis by which Sox17 regulates the secretory pathway in β cells, we performed microarray analysis on isolated islets following a 24-hour pulse of Sox17 overexpression.

2014-07-31 | GSE59928 | GEO

E-GEOD-61167

Project description:Expression data from mammary epithelial cells harvested from 8-9 week old C3H female mice - various isolation conditions

2015-08-05 | E-GEOD-61167 | ExpressionAtlas

E-MTAB-5264

Project description:Microarray analysis of islets of Langerhans from 3 week-old NOD, NOR and C57Bl/6 mice

2020-07-10 | E-MTAB-5264 | ExpressionAtlas

E-GEOD-38218

Project description:Gene expression data from cortex of 9 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice

2014-10-27 | E-GEOD-38218 | ExpressionAtlas

E-GEOD-38219

Project description:Gene expression data from cortex of 15 week old wild type, R6/2, HDAC4het and R6/2::HDAC4het mice

2014-10-27 | E-GEOD-38219 | ExpressionAtlas

Expression data from 24 hours of Sox17 overexpression in pancreatic islets of a 16-week old mice

Project description:Secretion of insulin by pancreatic Î² cells in response to glucose is central for glucose homeostasis, and dysregulation of this process is a hallmark of the early stages of diabetes. We utilized a tetracycline-inducible approach to investigate the immediate impact of a pulse of Sox17 expression on the insulin secretory pathway. Sox17 gain-of-function animals (Sox17-GOF) were generated using an Ins2-rtTA mouse line and a line in which Sox17 expression is regulated by the tetracycline transactivator (tetO-Sox17). Administering doxycycline to 16-week old mice resulted in Sox17 overexpression in mature Î² cells in the islets. In order to identify the molecular basis by which Sox17 regulates the secretory pathway in Î² cells, we performed microarray analysis on isolated islets following a 24-hour pulse of Sox17 overexpression. We chose to analyze a 24 hour pulse of Sox17 for islet pancreas RNA extraction and hybridization on Affymetrix microarrays since it was sufficient to stimulate the insulin secretory pathway without causing changes in islet architecture.

2014-07-31 | E-GEOD-59928 | biostudies-arrayexpress

E-GEOD-17499

Project description:Expression data from 2-week-old Arabidopsis untreated seedlings grown under a short day condition

2015-05-15 | E-GEOD-17499 | ExpressionAtlas

E-GEOD-21860

Project description:RNA-seq of pancreatic islets from pregnant mice

2019-05-14 | E-GEOD-21860 | ExpressionAtlas

E-GEOD-39514

Project description:Effects of H2be ectopic over-expression on gene expression in the main olfactory epithelium (MOE) of 5-week old mice.

2015-09-29 | E-GEOD-39514 | ExpressionAtlas