Project description:Pharmacological inhibition of the SMARCA4 bromodomain inhibited human leukemic cell proliferation, phenocopying SMARCA4 knockdown in these cells. We performed microarray analysis of global gene expression changes in MV4-11 cells after 6 days of PFI-3 treatment and after SMARCA4 knock-down. With this analysis we identified several genes whose expression was similarly up- or down-regulated upon inhibitor treatment and SMARCA4 depletion. Human acute monocytic leukemia cells (MV4-11, ACC 102) were lentivirally transduced with shRNA taregting SMARCA4 (KD) or with a negative control shRNA (Scr). In a parallel experiment MV4-11 cells were treated for 6 days with 10 uM PFI-3, which is SMARCA4, SMARCA2 and PBRM1 bromodomain inhibitor, or DMSO as a negative control. All sample types were prepared in triplicates.

2015-07-12 | E-GEOD-67920 | biostudies-arrayexpress

Expression data of Hmg20 knock down I/11 cells and controls

Project description:We performed microarray analysis to investigate the gene expression profile changes induced by Hmg20b knock down in I/11 cells.

2011-10-19 | GSE29169 | GEO

Homo sapiens

Project description:Gene expression analysis upon stable SmcHD1 Knock Down

| PRJNA226720 | ENA

Homo sapiens

Project description:Gene expression alterations upon knock down of transcription factors

| PRJNA357033 | ENA

Gene expression profiling of AGS Gastric Cancer cells upon YY1 knock down

Project description:Gene expression profiling of AGS Gastric Cancer cells upon YY1 knock down

| PRJNA685137 | ENA

Expression data of Hmg20 knock down I/11 cells and controls

Project description:We performed microarray analysis to investigate the gene expression profile changes induced by Hmg20b knock down in I/11 cells. Three normal and three Hmg20b knocked down I/11 cell Samples were examined.

2011-10-18 | E-GEOD-29169 | biostudies-arrayexpress