Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-GEOD-6928

ABSTRACT: Transcription profiling by array of Drosophila ovarian cells mutant for bam and stwl

OTHER RELATED OMICS DATASETS IN: PRJNA99355

PROVIDER: E-GEOD-6928 | ExpressionAtlas | 2014-09-02

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-GEOD-6928-analysis-methods.tsv	Tabular
	E-GEOD-6928-atlasExperimentSummary.Rdata	Rdata
	E-GEOD-6928-configuration.xml	Xml
	E-GEOD-6928-percentile-ranks.tsv	Tabular
	E-GEOD-6928.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 61

Similar Datasets

Chromatin Proteome of Drosophila Ovarian somatic cells

Project description:Chromatin Proteome was enriched from drosophila ovarian somatic cells using ChEP.

2021-07-02 | PXD024167 | JPOST Repository

Copy number profiling of 36 ovarian tumors on Affymetrix 100K SNP arrays and 16 ovarian tumors on 500K SNP arrays

Project description:Copy number profiling of 36 ovarian tumors on Affymetrix 100K SNP arrays Thirty-six ovarian tumors were profiled for copy-number alterations with the Affymetrix 100K Mapping Array. Copy number profiling of 36 ovarian tumors on Affymetrix 500K SNP arrays Sixteen ovary tumors were profiled for copy-number alterations with the high-resolution Affymetrix 500K Mapping Array.

2010-12-16 | GSE26075 | GEO

Piwi negatively regulates Polycomb Group proteins in maintaining germline stem cells and oogenesis

Project description:Piwi regulates niche and intrinsic mechanisms to maintain germline stem cells in Drosophila, yet how this regulation occurs remains elusive. Here, we show that Piwi interacts with the Polycomb Group Complexes PRC1 and PRC2 to maintain ovarian germline stem cells and oogenesis, as well as to repress retrotransposons. Piwi binds to PRC2 subunits Su(z)12 and Esc in vitro and forms a complex with PRC2 in vivo. Whole-genome analyses of PRC2-mediated histone 3 lysine 27 trimethylation (H3K27m3) in wild type and piwi mutant ovarian nuclei indicate that Piwi inhibits H3K27m3 at PRC2 target genes that are mostly regulators of development and transcription.

2017-01-03 | GSE40150 | GEO

piRNA production requires heterochromatin formation in Drosophila

Project description:Here, we analyzed two small RNA libraries derived from ovarian tissue mutant for either the Drosophila SETDB1 gene, or the Bam gene. Here we show that deposition of histone 3 lysine 9 by the methyltransferase dSETDB1 (egg) is required for piRNA cluster transcription. In the absence of dSETDB1, cluster precursor transcription collapses in germline and somatic gonadal cells and TEs are activated, resulting in germline loss and a block in germline stem cell differentiation. We propose that heterochromatin protects the germline by activating the piRNA pathway. Keyword : Epigenetics

2011-08-15 | GSE30086 | GEO

Homo sapiens

Project description:HCT116 cells transcription array

| PRJNA486219 | ENA

Homo sapiens

Project description:HCT116 cells transcription array

| PRJNA486220 | ENA

Ovarian cancer cell line study

Project description:An ovarian cancer cell line study to identify possible trends between chromosomal aberrations depicted from CGH microarray profiling with expression profiling. CGH microarray profiles of a panel of ovarian cancer cell lines will be analysed and 10 cell lines with chromosomal aberrations of recurrent regions (with the strongest trend) will be taken forward for further expression array analysis to identify candidate genes. CGH microarray analyses will restrict the regions of aberrations with high resolution and accurracy, combined with expression array analysis to pinpoint candidate genes that will relate to the amplified and deleted regions. Identified candidates will allow the better understanding of mechanisms and specific pathways involved in ovarian cancer development.

2008-08-29 | GSE12523 | GEO

piwi mutations and c-Fos overexpression on Drosophila ovarian germline

Project description:This project aims to identify molecular effects of piwi mutations and c-Fos overexpression on the formation of Drosophila ovarian germline RNA-seq was utilized to compare transcript levels between wild type, piwi mutant, and c-Fos over-expressing ovarian tissues

2017-02-08 | GSE69722 | GEO

Piwi regulates the usage of alternative transcription start sites in the Drosophila ovary

Project description:Transcription from alternative transcription start sites (TSSs) is prevalent among mammalian genes and has important biological functions. However, how TSSs are selected remains elusive. We identified 87 genes with altered TSS usage (ATU) in Piwi-deficient Drosophila ovaries using the cap-analysis gene expression sequencing (CAGE-seq) method. Piwi regulates TSS usage of ATU genes in germ cells and somatic cells in ovaries as well as in cultured ovarian somatic cells (OSCs). Correspondingly, RNA Pol II initiation and elongation at TSSs of ATU genes were affected in germline-piwi-knockdown ovaries and piwi-knockdown OSCs. We identified a FACT complex component, Ssrp, as a novel interactor of Piwi in the nucleus. Temporally controlled knockdown of ssrp affected TSS usage of ATU genes whereas overexpression of ssrp partially rescued the TSS usage of ATU genes in piwi mutant ovaries. Thus, Piwi may interact with Ssrp to regulate TSS usage in Drosophila ovaries by affecting Pol II initiation and elongation.

2024-11-29 | GSE277263 | GEO

piRNA production requires heterochromatin formation in Drosophila

2011-08-15 | E-GEOD-30086 | biostudies-arrayexpress