E-GEOD-73175
Ontology highlight
ABSTRACT:
PROVIDER: E-GEOD-73175 | ExpressionAtlas | 2016-05-13
REPOSITORIES: ExpressionAtlas
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| E-GEOD-73175-analysis-methods.tsv | Tabular | |||
| E-GEOD-73175-atlasExperimentSummary.Rdata | Rdata | |||
| E-GEOD-73175-coexpressions.tsv.gz | Tabular | |||
| E-GEOD-73175-configuration.xml | Xml | |||
| E-GEOD-73175-factors.xml | Xml |
Items per page: 5 1 - 5 of 29 |
Shared Molecules
Only show the datasets with similarity scores above: 0.545
Similar Datasets
Project description:RNA sequencing of primary thymic, bone and skin mesenchymal cells
| PRJNA296077 | ENA
Project description:Expression data from Evi1-transduced primary bone marrow cells
2015-09-15 | E-GEOD-22434 | ExpressionAtlas
Project description:Purpose : Elucidate post-natal role of SCA1+ thymic mesenchymal cells (tMCs) and evaluate the functional overlap between thymic, bone and skin MCs. Method : By high speed cell sorting, we isolated primary MCs (Lin- SCA1+ cells) from mouse thymus, bone and skin. We extracted their respective total RNA and compared their transcriptome by high-throughput RNA-sequencing. Results : We found a total of 2036 differentially expressed genes (FC>5, p-adj<0.1 and RPKM>1) between the 3 MC populations. IPA analyses revealed that each MC population was enriched for genes associated to phagocyte chemotaxis. We also denoted 2850 genes with shared expression across MC populations. IPA analysis of those shared genes also revealed an enrichment for genes influencing phagocyte migration, chemotaxis and function. Finally, MC transcriptomes showed that all 3 MC populations were expressing genes associated with hematopoietic stem and progenitor cell (HSPC) support, strongly suggesting that MCs from thymic, bone and skin all possess the ability to support HSPCs. Conclusion : Overall, our study highlighted 3 potential novel roles for tMCs : 1) Promoting macrophage/monocyte chemotaxis, 2) Enhacing the apoptotic cell clearance process and 3) setting an inviting niche for hematopoietic progenitors. These novel biological roles for tMCs could have substantial effets on thymic biology. Finally, our RNA-seq data offer a valuable resource to the community that can be mined to explore multiple questions related mesenchymal cell biology. Transcriptome comparison between MC populations
2016-02-26 | E-GEOD-73175 | biostudies-arrayexpress
Project description:RNAseq of human bone marrow mesenchymal stem cells in co-culture with endothelial cells
2025-01-23 | E-MTAB-6849 | ExpressionAtlas
Project description:Purpose : Elucidate post-natal role of SCA1+ thymic mesenchymal cells (tMCs) and evaluate the functional overlap between thymic, bone and skin MCs. Method : By high speed cell sorting, we isolated primary MCs (Lin- SCA1+ cells) from mouse thymus, bone and skin. We extracted their respective total RNA and compared their transcriptome by high-throughput RNA-sequencing. Results : We found a total of 2036 differentially expressed genes (FC>5, p-adj<0.1 and RPKM>1) between the 3 MC populations. IPA analyses revealed that each MC population was enriched for genes associated to phagocyte chemotaxis. We also denoted 2850 genes with shared expression across MC populations. IPA analysis of those shared genes also revealed an enrichment for genes influencing phagocyte migration, chemotaxis and function. Finally, MC transcriptomes showed that all 3 MC populations were expressing genes associated with hematopoietic stem and progenitor cell (HSPC) support, strongly suggesting that MCs from thymic, bone and skin all possess the ability to support HSPCs. Conclusion : Overall, our study highlighted 3 potential novel roles for tMCs : 1) Promoting macrophage/monocyte chemotaxis, 2) Enhacing the apoptotic cell clearance process and 3) setting an inviting niche for hematopoietic progenitors. These novel biological roles for tMCs could have substantial effets on thymic biology. Finally, our RNA-seq data offer a valuable resource to the community that can be mined to explore multiple questions related mesenchymal cell biology.
2016-02-26 | GSE73175 | GEO
Project description:Transcription profiling by high throughput sequencing of three populations of primary dentate gyrus cells
2019-05-14 | E-GEOD-68270 | ExpressionAtlas
Project description:Transcription profiling by high throughput sequencing of human fetal differentiated P0 retinal pigment epithelial cells, mesenchymal P4 cells, and A-83-01 rescued P4 cells
2025-01-17 | E-GEOD-67898 | ExpressionAtlas
Project description:Transcription profiling by array of human bone marrow mesenchymal stem cells after treatment with BMP2 or TGFbeta-3
2025-01-16 | E-GEOD-10315 | ExpressionAtlas
Project description:Transcription profiling by array of human bone marrow mesenchymal stem cells overexpressing Dlk1
2025-01-22 | E-MEXP-560 | ExpressionAtlas
Project description:Transcription profiling of human primary bone cells exposed to Staphylococcus aureus
2025-01-23 | E-MTAB-6700 | ExpressionAtlas