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E-MEXP-1413

ABSTRACT: Transcription profiling of liver from mouse EF2 mutants vs wild type to investigate the role of E2F2 in liver regeneration

PROVIDER: E-MEXP-1413 | ExpressionAtlas | 2015-10-22

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-MEXP-1413-analysis-methods.tsv	Tabular
	E-MEXP-1413-atlasExperimentSummary.Rdata	Rdata
	E-MEXP-1413-configuration.xml	Xml
	E-MEXP-1413-percentile-ranks.tsv	Tabular
	E-MEXP-1413.condensed-sdrf.tsv	Tabular

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Transcription profiling of liver from mouse EF2 mutants vs wild type to investigate the role of E2F2 in liver regeneration

Project description:E2F transcription factors are key regulators of cell cycle progression. They are fundamental for crossing the G1/S checkpoint as some of their targets are promoters of essential genes for replication. To analyse the importance of E2F2 in liver regeneration it has been used the well characterised paradigm of 70% partial hepatectomy in both wild-type (wt) and E2F2-/- mice. To see whether the lack of transcription factor E2F2 has any effect over the regenerative process, changes in gene expression profile have been analysed by Affymetrix microarray technology in both wt and E2F2-/- mice.

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