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Transcription profiling of duodenum biopsies from patients with celiac disease taken at time of diagnosis or after two years of a gluten free diet

ABSTRACT: Study on the effects of long term, dietary, consumption of gliadin (gluten) in patients with celiac disease. Comparison of expression profiles of biopsies from normalized patients treated with gluten-free diet >2 years (FU-follow-up samples) versus biopsies from patients with active disease (Dx-at diagnosis samples)

REANALYSIS of: E-MEXP-1828

ORGANISM(S): Homo sapiens

PROVIDER: E-MEXP-1828 | ExpressionAtlas | 2015-10-22

REPOSITORIES: ExpressionAtlas

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Publications

Long-term and acute effects of gliadin on small intestine of patients on potentially pathogenic networks in celiac disease.

Castellanos-Rubio Ainara A Santin Izortze I Martin-Pagola Ainhoa A Irastorza Iñaki I Castaño Luis L Vitoria Juan Carlos JC Bilbao Jose Ramon JR

Autoimmunity 20100301 2

Celiac disease (CD) is a complex, immune-mediated intolerance to gliadin that develops in genetically susceptible individuals. Although the main driving force of the disease is an aberrant autoimmune response, several other pathogenic mechanisms, many still unidentified, are also involved. In order to describe at a network level the alterations provoked by a gliadin insult on the intestinal mucosa of patients, we compared the expression profiles of biopsies from 9 active and 9 treated patients ( ...[more]

PMID: 19814655

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