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E-MEXP-2070

ABSTRACT: Transcription profiling by array of Drosophila head and thorax from females mated with sex peptide null or sex peptide producing males

PROVIDER: E-MEXP-2070 | ExpressionAtlas | 2015-10-22

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MEXP-2070-analysis-methods.tsv	Tabular
	E-MEXP-2070-atlasExperimentSummary.Rdata	Rdata
	E-MEXP-2070-configuration.xml	Xml
	E-MEXP-2070-percentile-ranks.tsv	Tabular
	E-MEXP-2070.condensed-sdrf.tsv	Tabular

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E-MEXP-2074

Project description:Transcription profiling of Drosophila abdomen from females mated with sex peptide null or sex peptide producing males

2015-10-22 | E-MEXP-2074 | ExpressionAtlas

Transcription profiling by array of Drosophila head and thorax from females mated with sex peptide null or sex peptide producing males

Project description:Comparison of females mated to males null for Sex-Peptide (SP0, Liu, H. and E. Kubli, Sex-peptide is the molecular basis of the sperm effect in Drosophila melanogaster. Proc Natl Acad Sci U S A, 2003. 100(17): p. 9929-33) or to control, Sex-Peptide producing, males. Comparisons were made at 3 and 6 hours after mating, in dissected Head-Thorax body parts.

2009-08-01 | E-MEXP-2070 | biostudies-arrayexpress

MicroRNA profiling of Drosophila head and thorax from females mated with sex peptide null or sex peptide producing males

2009-08-01 | E-MEXP-2079 | biostudies-arrayexpress

Transcription profiling of Drosophila abdomen from females mated with sex peptide null or sex peptide producing males

2009-08-01 | E-MEXP-2074 | biostudies-arrayexpress

MicroRNA profiling of Drosophila abdomen from females mated with sex peptide null or sex peptide producing males

2009-08-01 | E-MEXP-2080 | biostudies-arrayexpress

Time series RNA-seq of the Drosophila melanogaster female response to mating and Sex Peptide.

Project description:Sex Peptide, a seminal fluid protein of Drosophila melanogaster males, elicits an array of post-mating responses in females, including decreased receptivity to re-mating, and increased egg laying, activity and food intake, with a preference for protein-rich food. To determine how one protein can have such widespread effects, we set out to dissect the genetic architecture of the female’s response to Sex Peptide, to determine whether Sex Peptide alters the expression of several regulators targeted to specific post-mating responses or acts on a pleiotropic regulator that controls multiple responses. We performed bulk RNA-seq of female heads at 10 time points within the first 24 hours after mating, sampling virgin females, females mated to control males and females mated to Sex Peptide-null males. Using this high-resolution time series, we identified mating- and Sex Peptide-dependent differentially expressed genes and discovered the presence of differentially used exons. We constructed gene regulatory networks using clustering and motif enrichment analyses, and identified cell types in which these changes might take place using deconvolution of our bulk RNA-seq dataset. One key network included metabolic genes which might change in expression in the female’s fat body. A second network included genes with neuronal functions, whose changes might be located in neurons or sensory organs in the female’s head. Within these networks we identified known molecular regulators of the circadian clock. Further, we found that many differentially expressed genes, and some differentially used exons, followed a circadian rhythm in virgin females, and that this rhythm was altered after mating with a Sex Peptide- male.

2023-01-27 | GSE198879 | GEO

Transcriptome profiles of virgin and mated Callosobruchus maculatus seed beetles

Project description:Objective: Sexually dimorphic phenotypes arise largely from sex-specific gene expression, which has mainly been characterized in sexually naïve adults. However, we expect sexual dimorphism in transcription to be dynamic and dependent on factors such as reproductive status. Mating induces many behavioral and physiological changes distinct to each sex and is therefore expected to activate regulatory changes in many sex-biased genes. Methods: Using RNA-seq we first characterized sexual dimorphism in gene expression, for the first time in Callosobruchus maculatus seed beetles. We then examined how females and males respond to mating and how it affects sex-biased expression, both in more sex-limited (abdomen) and sex-shared (head and thorax) tissues. Results: Mating responses were largely sex-specific and, as expected, females showed more numerous changes compared to males. Of the sex-biased genes present in virgins, 16% (1,041 genes) in the abdomen and 17% (243 genes) in the head and thorax altered their relative expression between the sexes. Sex-bias status changed in 2% of the genes in the abdomen and 4% in the head and thorax following mating. Mating responses involved de-feminization of females and, to a lesser extent, de-masculinization of males relative to their virgin state: mating decreased rather than increased dimorphic expression of sex-biased genes.

2016-12-23 | GSE92855 | GEO

E-GEOD-8514

Project description:Transcription profiling by array of human adrenal gland aldosterone-producing adenoma

2025-01-24 | E-GEOD-8514 | ExpressionAtlas

E-GEOD-76567

Project description:Transcription profiling by high throughput sequencing of hippocampus from adult males and females of six inbred strains of mice

2019-05-14 | E-GEOD-76567 | ExpressionAtlas

Adverse Impact of Female Reproductive Signaling on Age-Dependent Neurodegeneration After Mild Head Trauma in Drosophila

Project description:Environmental insults, including mild head trauma, significantly increase the risk of neurodegeneration. However, it remains challenging to establish a causative connection between early-life exposure to mild head trauma and late-life emergence of neurodegenerative deficits, nor do we know how sex and age compound the outcome. Using aDrosophilamodel, we demonstrate that exposure to mild head trauma causes neurodegenerative conditions that emerge late in life and disproportionately affect females. Increasing age-at-injury further exacerbates this effect in a sexually dimorphic manner. We further identify Sex Peptide (SP) signaling as a key factor in female susceptibility to post-injury brain deficits. RNA sequencing highlights changes in innate immune defense transcripts specifically in mated females during late life. Our findings establish a causal relationship between early head trauma and late-life neurodegeneration, emphasizing sex differences in injury response and the impact of age-at-injury. Finally, our findings reveal that reproductive signaling adversely impacts female response to mild head insults and elevates vulnerability to late-life neurodegeneration.

2024-08-29 | GSE274136 | GEO

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