Transcriptomics,Multiomics

Dataset Information

146

Transcription profiling by array of human primary lung adenocarcinomas


ABSTRACT: Gene transcription in a set of 49 human primary lung adenocarcinomas and 9 normal lung tissue samples was examined using Affymetrix GeneChip technology. We aimed to investigate differential gene expression between the two tissue types. A total of 3,442 genes, called the set MAD, were found to be either up- or down-regulated by at least two fold between the two phenotypes. Genes assigned to a particular gene ontology term were found, in many cases, to be significantly unevenly distributed between the genes in and outside MAD. Terms that were overrepresented in MAD included functions directly implicated in cancer cell metabolism. Based on their functional roles and expression profiles, genes in MAD were grouped into likely co-regulated gene sets.

REANALYSIS of: E-MEXP-231

ORGANISM(S): Homo sapiens  

DISEASE(S): lung adenocarcinoma

PROVIDER: E-MEXP-231 | ExpressionAtlas | 2014-07-03

REPOSITORIES: ExpressionAtlas

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Publications

Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressor.

Kwak Youn-Tae YT   Radaideh Sofyan M SM   Ding Lianghao L   Li Rui R   Frenkel Eugene E   Story Michael D MD   Girard Luc L   Minna John J   Verma Udit N UN  

Molecular cancer research : MCR 20110211 3


The catalytic subunits of IκB kinase (IKK) complex, IKKα and IKKβ, are involved in activation of NF-κB and in mediating a variety of other biological functions. Though these proteins have a high-sequence homology, IKKα exhibits different functional characteristics as compared with IKKβ. Earlier, we have shown that cyclin D1 is overexpressed and predominantly localized in the nucleus of IKKα(-/-) cells, indicating that IKKα regulates turnover and subcellular distribution of cyclin D1, which is me  ...[more]

Publication: 1/2

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