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E-MEXP-3098

ABSTRACT: Transcription profiling by array of colon tissues from mice resistant (BALB/c) and susceptible (AKR) to T. muris infection to study infection-induced colitis against uninfected controls

PROVIDER: E-MEXP-3098 | ExpressionAtlas | 2014-10-17

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MEXP-3098-analysis-methods.tsv	Tabular
	E-MEXP-3098-atlasExperimentSummary.Rdata	Rdata
	E-MEXP-3098-configuration.xml	Xml
	E-MEXP-3098-percentile-ranks.tsv	Tabular
	E-MEXP-3098.condensed-sdrf.tsv	Tabular

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Gene expression profiling of mouse chronic intestinal inflammation

Project description:Trichuris muris (T. muris) induces chronic colitis in susceptible mouse strains with clinical, histological, and immunological homology to human Crohn's disease. Gene expression profiling was performed on colon tissue of resistant (BALB/c) and susceptible (AKR) mice following T. muris infection.

2013-05-13 | E-MEXP-3098 | biostudies-arrayexpress

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Transcriptome profiling of gene expression in the colon tissues of steady state and Helicobacter hepaticus-infected 129SvEvS6.Rag2−/− mice and the congenic strain 129.C3B.Rag2−/− R17

Project description:Chronic inflammation of the intestine has been associated with an elevated risk of developing colorectal cancer. Recent association studies have highlighted the role of genetic predisposition in the etiology of colitis and started to unravel its complexity. However, the genetic factors influencing the progression from colon inflammation to tumorigenesis are not known. We used Helicobacter hepaticus-induced colitis in a 129.RAG(-/-) mouse model to explore early onset of the disease. Experiments purpose and justifications: to elucidate early genes and pathways changed in the mouse strain susceptible to innate colitis triggered by Hh infection. Experimental factors: steady state, and days 2 and 4 of infection (n=4 mice per condition). The time course is validated on the same samples using qPCR for inflammatory genes. Samples: RNA from proximal mouse colon. Two mouse genetic strains are compared 129Rag-/- (susceptible) and 129.R17Rag-/- (protected from colitis).

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Project description:Human colon biopsies (healthy and Ulcerative Colitis) LC-MS/MS

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Project description:Cerebral malaria (CM) is a leading cause of death in the world. Better understanding of the pathogenesis of this disease is critical for the development of novel therapies. In this work, we investigated temporal gene expression profiles in the brains of CM-susceptible and CM-resistant mice during infection with P. Berghia ANKA (PbA). In this model of CM, susceptible mice develop neurological signs by day 6 post infection while resistant mice do not develop neurological manifestations during malarial infection. Experiment Overall Design: C57/B6 (CM-susceptible) and Balb/C (CM-resistant) mice were infected with PbA. Gene expression profiles from whole brains were obtained at day 0 (uninfected), day 1, day 3, and day 6.

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