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E-MEXP-804

ABSTRACT: Transcription profiling of human pancreas from patients with autoimmune pancreatitis and alcohol-induced chronic pancreatitis

PROVIDER: E-MEXP-804 | ExpressionAtlas | 2025-01-22

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-MEXP-804-analysis-methods.tsv	Tabular
	E-MEXP-804-atlasExperimentSummary.Rdata	Rdata
	E-MEXP-804-configuration.xml	Xml
	E-MEXP-804-percentile-ranks.tsv	Tabular
	E-MEXP-804.condensed-sdrf.tsv	Tabular

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Transcription profiling of human pancreas from patients with autoimmune pancreatitis and alcohol-induced chronic pancreatitis

Project description:Autoimmune pancreatitis (AIP) is a recently identified disease of the pancreas with unknown etiology and antigens. The aim of this study was to determine new target antigens and differentially regulated genes and proteins by means of transcriptomics and proteomics and to validate them in patients with autoimmune pancreatitis. Here we report a distinct downregulation at the RNA and protein level of pancreatic proteases (anionic trypsinogen, cationic trypsinogen, mesotrypsinogen, elastase IIIB) and pancreatic stone protein in autoimmune pancreatitis in comparison to alcohol-induced chronic pancreatitis.

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