Transcriptomics

Dataset Information

15

Transcription profiling by array of serrate-1 mutant Arabidopsis seedlings


ABSTRACT: microRNAs function as sequence-specific guides to regulate genes by post-transcriptional gene silencing. Many miRNAs are involved in the control plant development by regulating the accumulation of transcripts encoding transcription factors. This causes pleiotropic developmental phenotypes of mutants defective in miRNA accumulation, such as dcl1, hen1, hyl1 and ago1. The serrate-1 (se-1) mutant of Arabidopsis also exhibits a highly pleiotropic phenotype which overlaps with phenotypes of mutants defective in miRNA accumulation. It has been proposed that SE functions specifically in miRNA-mediated repression of the leaf polarity genes PHABULOSA and PHAVOLUTA. Microarray analysis of transcript levels in se-1 compared to wild-type however revealed upregulation of many genes known to be targets of miRNA regulation. We show that SE is a general regulator of miRNA levels probably controlling processing of pri-miRNA to miRNA.

REANALYSIS of: E-MEXP-838

ORGANISM(S): Arabidopsis thaliana  

PROVIDER: E-MEXP-838 | ExpressionAtlas | 2015-11-17

REPOSITORIES: ExpressionAtlas

Dataset's files

Source:
Action DRS
E-MEXP-838-analysis-methods.tsv Tabular
E-MEXP-838-atlasExperimentSummary.Rdata Rdata
E-MEXP-838-configuration.xml Xml
E-MEXP-838-percentile-ranks.tsv Tabular
E-MEXP-838.condensed-sdrf.tsv Tabular
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Publications

SERRATE: a new player on the plant microRNA scene.

Lobbes Dajana D   Rallapalli Ghanasyam G   Schmidt Dominik D DD   Martin Cathie C   Clarke Jonathan J  

EMBO reports 20060915 10


MicroRNAs (miRNAs) function as sequence-specific guides that control gene expression by post-transcriptional gene silencing. Many miRNAs influence plant development by regulating the accumulation of transcripts that encode transcription factors. Mutants defective in miRNA accumulation, such as dcl1, hen1, hyl1 and ago1, have pleiotropic developmental phenotypes. The serrate-1 (se-1) mutant of Arabidopsis also shows a highly pleiotropic phenotype, which overlaps with the phenotypes of mutants def  ...[more]

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