Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-10233

ABSTRACT: RNA-seq of oocytes and zygotes from pabpn1l ko and wt female mice

PROVIDER: E-MTAB-10233 | ExpressionAtlas | 2023-06-15

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-10233-analysis-methods.tsv	Tabular
	E-MTAB-10233-analytics.tsv	Tabular
	E-MTAB-10233-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-10233-configuration.xml	Xml
	E-MTAB-10233-g3_g1-mvaPlot.png	Other

Items per page:

1 - 5 of 35

Similar Datasets

RNA-seq of pabpn1l ko and wt female mice oocytes and zygotes

Project description:RNA-seq of pabpn1l ko and wt female mice oocytes and zygotes

| PRJEB40052 | ENA

RNA-seq of oocytes and zygotes from pabpn1l ko and wt female mice

Project description:RNA-seq of oocytes and zygotes from pabpn1l ko and wt female mice

| PRJEB43700 | ENA

RNA-Sequencing analysis of liver tissue from female Foxa3-Cre YAP1 knockout mice, Foxa3-Cre YAP1 KO TAZ heterozygous mice, and WT littermate controls, at 3-4 months of age

Project description:We developed a mouse model of bile duct paucity by deleting Yes-associated protein 1 (YAP1) in foregut endoderm progenitors, using the Foxa3 promoter to drive Cre expression. YAP1 KO mice are viable postnatally and survive long-term despite a complete failure of intrahepatic bile duct development, resembling the liver phenotype of Alagille syndrome. Adult YAP1 KO mice suffer from severe chronic cholestasis, but show minimal hepatocellular injury, suggesting that the hepatocytes have adapted to preserve liver function and reduce damage from the toxicity of bile acids and bilirubin. We next bred Foxa3-Cre YAP1 KO TAZ heterozygote and Foxa3-Cre YAP1 KO TAZ KO (DKO) mice to assess the role of TAZ in this model. DKO mice and male YAP KO TAZ heterozygotes died around time of birth. The survivors, YAP1 KO TAZ heterozygote females, were overall phenotypically similar to YAP1 KO mice, with absence of intrahepatic bile ducts and long-term survival. We used RNA-seq to analyze the gene expression patterns of whole liver tissue of female adult YAP1 KO mice compared to WT controls (C57BL/6 background), and female adult YAP1 KO TAZ heterozygote (YKTH) mice compared to WT controls (mixed C57BL/6 - FVB background). We found that both YAP1 KO and YAP1 KO TAZ heterozygote female mice were overall very similar and showed similar alterations in gene expression compared to WT. There were a few differences in pathways involved in cell cycling and monocyte recruitment.

2023-07-20 | GSE213815 | GEO

RNA-seq analysis of WT and βOGT KO female islets

Project description:RNA-seq analysis of WT and βOGT KO female islets

| PRJNA604803 | ENA

Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice [exp2]

Project description:RNA-sequencing data of female lumbar dorsal horn spinal cord microglia from WT or Treg KO mice after 3 days of CSF1 i.t. injection.

2021-09-27 | GSE184800 | GEO

Foxa1 and Foxa2 are Required for Sexual Dimorphism in Liver Cancer - Gene Expression

Project description:Gene expression changes between livers of treated WT and dKO (Foxa1 and Foxa2 KO) male and female mice and untreated female (WT and dKO) mice were measured to identify pathways related to Foxa1/2 regulation of pathways involved in liver cancer.

2012-01-20 | GSE32244 | GEO

Project description:RNA-Seq of WT and Tollip-KO mice liver

| PRJNA543694 | ENA

Expression data of MCK conditional frataxin knock-out mice

Project description:Frataxin deficiency in human is the cause of Friedreich's ataxia (FA), a lethal neuro- and cardio-degenerative disease. Knock-out (KO) mice of this mouse model of FA exhibit classical cardiomyopathy of the patients. The onset of FA phenotypes in the KO mice is approximately 6-7 weeks of age. This genearray analysis was conducted to examine the changes in gene expression in the heart of KO mice relative to their wild-type (WT) littermates at 4- and 10-weeks of age. At 10-weeks of age, the KO mice begin to die from severe cardiomyopathy. RNA from the heart of four female 4-week-old MCK littermates (two WT and two KO) and four female 10-week-old MCK littermates (two WT and two KO) was extracted and hybridised to Affymetrix Mouse Genome 430 2.0 Array.

2011-12-31 | E-GEOD-31208 | biostudies-arrayexpress

RNA-seq from oocytes and zygotes of pabpn1l ko and wt female mice during different stages

Project description:RNA-seq from oocytes and zygotes of pabpn1l ko and wt female mice during different stages

| PRJEB43597 | ENA

Transcriptional and genomic occupancy profiling from MLX WT and MLX knockout mouse tissues.

Project description:We generated mice null for MAX-like Protein X (MLX), encoded by Mlx. All male mice are sterile. We profiled testes tissue from WT versus KO mice by RNA-Seq. We performed ChIP-Seq on WT and KO testes for MLX and MAX, as well as ChIP-Seq for MLX and MAX from primary B220+ splenic B cells, and ChIP-Seq for MLX, MAX and MNT from 3T3 cell lines derived from WT and KO embryos.

2021-07-31 | GSE165820 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data