Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-10469

ABSTRACT: RNAseq of Huh7 and Huh7.5 cells treated with interferon alpha, beta or lambda.

PROVIDER: E-MTAB-10469 | ExpressionAtlas | 2025-07-07

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-10469-analysis-methods.tsv	Tabular
	E-MTAB-10469-analytics.tsv	Tabular
	E-MTAB-10469-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-10469-configuration.xml	Xml
	E-MTAB-10469-g4_g1-mvaPlot.png	Other

Items per page:

1 - 5 of 82

Similar Datasets

RNAseq of Huh7 and Huh7.5 cells treated with interferon alpha, beta or lambda.

Project description:RNAseq of Huh7 and Huh7.5 cells treated with interferon alpha, beta or lambda.

| PRJEB44928 | ENA

RNAseq of Huh7 and Huh7.5 cells treated with interferon alpha, beta or lambda.

Project description:The transcriptome of Huh7 and Huh7.5 was sequenced from cells treated with interferon alpha (IFNα), beta (IFNβ) or lambda (IFNλ) for 8 hours. Each treatment was compared to respective mock-treated cells in 6 pairwise comparisons, for a total of 43 samples classified in 12 experimental conditions. Cells were treated for 8h with 10ng/ml of Interferon-α2A, 5000 U/ml of Interferon-β1A or 100ng/ml of interferon-λ3 prior RNA extraction and library preparation. Mock-treated cells were used as control for each treatment. 3 to 4 biological replicates were analysed for each biological condition. Libraries for Illumina sequencing were constructed by polyA selection with the Illumina Kit. A paired end (2x100) run was performed.

2021-08-17 | E-MTAB-10469 | biostudies-arrayexpress

mRNA microarray analysis of gene changes in Huh7 cells treated with IFN-λ4, IFN-λ1 and IFN-α

Project description:The change of gene expression in Huh7 cells treated with IFN-λ4, IFN-λ1 and IFN-α was analyzed at 0h, 6h and 16h after different interferon treatments.

2016-08-08 | GSE83085 | GEO

MX1 is Silenced in Permissive HRP4 Cells Supporting HCV Replication

Project description:MX1 is a well-characterized interferon-induced antiviral gene. MX1 is activated by viral infection due to interferon production in cells. We treated non-permissive Huh7 cells and permissive HRP4 cells with interferon. We compared the expression of genes induced by interferon to determine host factors affecting HCV replication. Huh7 cells and HRP4 cells were treated with 40U/ml interferon-Î± for 6h. RNA was extracted and hybridized on Affymetrix microarrays

2013-07-03 | E-GEOD-31903 | biostudies-arrayexpress

Primary human lung microvascular endothelial cells treated with universal interferon alpha beta or interferon gamma

Project description:The purpose is to obtain samples for mRNA analysis in primary human lung microvascular endothelial cells treated with universal interferon alpha beta or interferon gamma.

2017-12-27 | GSE106524 | GEO

Primary human lung microvascular endothelial cells treated with universal interferon alpha beta or interferon gamma

Project description:Primary human lung microvascular endothelial cells treated with universal interferon alpha beta or interferon gamma

| PRJNA417087 | ENA

Transcriptional response of intestinal epithelial cells to type I and III IFN

Project description:RNAseq of intestinal epithelial cell (IEC) organoids and treated with PBS, interferon beta (IFNB), or interferon lambda (IFNL). RNAseq of IECs sorted from neonatal mouse intestines following treatment with PBS, IFNB, or IFNL.

2019-12-18 | GSE142166 | GEO

Microarray analysis of IFN-response

Project description:Type I interferon (IFN-α/β) is the first line of defense against viral infection. Mouse models have been pivotal to our understanding of IFN-α/β in immunity, although validation of these findings in humans has not been possible. We investigated a previously healthy child with fatal susceptibility to the live-attenuated measles, mumps and rubella (MMR) vaccine. By targeted resequencing we identified a homozygous mutation in the high-affinity interferon-α/β receptor (IFNAR2), which rendered cells unresponsive to IFN-α/β and led to unrestricted replication of IFN-attenuated viruses. Reconstitution of patient cells with wild-type IFNAR2 restored IFN-α/β responsiveness and viral resistance. Despite the failure to control vaccine viruses, the patient showed no evidence of susceptibility to conventional viral pathogens in vivo and adaptive immunity appeared normal. Human IFNAR2 deficiency therefore reveals an essential role for IFN-α/β in resistance to attenuated viruses, but significant and unexpected redundancy overall in antiviral immunity. Total RNA isolated from IFNAR2-deficient patient (in triplicate) and control (three independent control lines) fibroblasts treated with IFNalpha, IFNbeta or IFNgamma (1000 IU/mL) for 10h

2015-06-12 | E-GEOD-67737 | biostudies-arrayexpress

MX1 is Silenced in Permissive HRP4 Cells Supporting HCV Replication

2013-07-03 | GSE31903 | GEO

Interferon response in Huh7 cells

Project description:Interferon response in Huh7 cells

| PRJNA649769 | ENA