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E-MTAB-10718

ABSTRACT: RNA-Seq of WT Flp-In T-REx 293, UPF3A knockout and UPF3A overexpression cell lines in part with additional siRNA-mediated control or UPF3B knockdowns

PROVIDER: E-MTAB-10718 | ExpressionAtlas | 2025-07-10

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-10718-analysis-methods.tsv	Tabular
	E-MTAB-10718-analytics.tsv	Tabular
	E-MTAB-10718-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-10718-configuration.xml	Xml
	E-MTAB-10718-g1_g4-mvaPlot.png	Other

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RNA-Seq of WT Flp-In T-REx 293, UPF3A knockout and UPF3A overexpression cell lines in part with additional siRNA-mediated control or UPF3B knockdowns

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Project description:UPF3A and UPF3B are paralogous genes in human cells that are involved in the nonsense-mediated decay (NMD) pathway. NMD is a cellular quality control mechanism that monitors mRNAs during translation. Aberrant translation due to features such as the presence of a premature stop codon downstream on an exon-exon junction activates NMD and leads to the degradation of the mRNA. To investigate the role of UPF3B and UPF3A in NMD, we have generated UPF3A knockout (KO) human Flp-In T-REx 293 cells using CRISPR-Cas9, as well as FLAG-tagged UPF3A overexpressing cells using the PiggyBac transposon system. We generated RNA-Sequencing data for wildtype, UPF3A KO and UPF3A overexpressing (OE) cells, in part with additional siRNA-mediated knockdown of Luciferase (Luc) as control or UPF3B.

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