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E-MTAB-11538

ABSTRACT: Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion - primary L cells

PROVIDER: E-MTAB-11538 | ExpressionAtlas | 2025-06-09

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-11538-analysis-methods.tsv	Tabular
	E-MTAB-11538-analytics.tsv	Tabular
	E-MTAB-11538-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-11538-configuration.xml	Xml
	E-MTAB-11538-g3_g1-mvaPlot.png	Other

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Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion - primary L cells

Project description:Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion - primary L cells

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Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion - mGLUTag L cells

Project description:Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion - mGLUTag L cells

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Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion - 16S

Project description:Nobiletin ameliorates high fat-induced disruptions in rhythmic glucagon-like peptide-1 secretion - 16S

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[E-MTAB-587] PCR_artifacts

Project description:WARNING: This library was yield low amount of material and it was over-amplified by PCR. This libraries are used study the robustness of several statitical methods against PCR artifacts. ChIP experiments were performed on Arabidopsis wildtype inflorescences using an antibody raised against a C-terminal peptide of SEP3. ArrayExpress Release Date: 2011-04-27 Publication Title: ChIP-seq Analysis in R (CSAR): An R package for the statistical detection of protein-bound genomic regions Publication Author List: Jose M. Muino, Kerstin Kaufmann, Roeland C. H. J. van Ham, Gerco C. Angenent, and Pawel Krajewski Person Roles: submitter Person Last Name: Muino Person First Name: Jose Person Mid Initials: M. Person Email: jose.muino@wur.nl Person Phone: 0317-481122 Person Address: Droevendaalsesteeg 1, P.O. Box 16, 6700 AA Wageningen, The Netherlands Person Affiliation: Plant Research International B.V.

2011-07-14 | GSE30616 | GEO

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Hemocytes and fat body cells, the only professional immune cell types in Drosophila, show strikingly different responses to systemic infection

Project description:The fruit fly Drosophila is an excellent model to study the response of different Q7 immunocompetent organs during systemic infection. In the present study, we intended to test the hypothesis that the only professional immune organs of the fly, the fat body and hemocytes, show substantial similarities in their responses to systemic infection. However, comprehensive transcriptome analysis of isolated organs revealed highly divergent transcript signatures, with the few commonly regulated genes encoding mainly classical immune effectors from the antimicrobial peptide family. The fat body and the hemocytes each have specific reactions that are not present in the other organ. Fat body-specific responses comprised those enabling an improved peptide synthesis and export. This reaction is accompanied by transcriptomic shifts enabling the use of the energy resources of the fat body more efficiently. Hemocytes, on the other hand, showed enhanced signatures related to phagocytosis. Comparing immune-induced signatures of both cell types with those of whole-body responses showed only a minimal correspondence, mostly restricted again to antimicrobial peptide genes. In summary, the two major immunocompetent cell types of Drosophila show highly specific responses to infection, which are closely linked to the primary function of the respective organ in the landscape of the systemic immune response.

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MOTS-c: A Novel Peptide Encoded by a Short Mitochondrial Open Reading Frame Regulates Metabolic Homeostasis

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Liver tissue HELP-tagging cytosine methylation data from C57BL/6J mice receiving high-fat diet with or without lingonberries

Project description:The C57BL/6J mouse model develops obesity and pre-diabetes when fed a high-fat diet. In this experiment, DNA methylation was assessed globally at specific CpG sites in liver tissue from mice receiving high-fat diet (45E% from fat) for 13 weeks (Control) or high-fat diet supplemented with 20% (w/w) of freeze-dried lingonberries (n=4). Our findings show that lingonberries prevent development of high-fat induced obesity, hepatic steatosis and low-grade inflammation, and the DNA was hypermethylated in mice receiving lingonberries compared to control. Genome wide hepatic DNA methylation comparison between mice fed high-fat diet with or without a lingonberry supplement (n=4/group).

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