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E-MTAB-12027

ABSTRACT: An in vitro effect of PPAR beta/delta ligands on transcriptomic profile of porcine corpus luteum during LPS-induced inflammation

PROVIDER: E-MTAB-12027 | ExpressionAtlas | 2025-05-29

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-12027-analysis-methods.tsv	Tabular
	E-MTAB-12027-analytics.tsv	Tabular
	E-MTAB-12027-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-12027-configuration.xml	Xml
	E-MTAB-12027-g5_g1-mvaPlot.png	Other

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An in vitro effect of PPAR beta/delta ligands on transcriptomic profile of porcine corpus luteum during LPS-induced inflammation

Project description:An in vitro effect of PPAR beta/delta ligands on transcriptomic profile of porcine corpus luteum during LPS-induced inflammation

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An in vitro effect of PPAR beta/delta ligands on transcriptomic profile of porcine corpus luteum during LPS-induced inflammation

Project description:The aim of this study was to determine the in vitro effects of peroxisome proliferator-activated receptor-beta/delta (PPARβ/δ) ligands on the transcriptomic profile of the LPS-stimulated pig CL in the mid-luteal phase of the estrous cycle using RNA-seq technology. The CL slices were incubated in the presence of LPS or in combination with LPS and the PPARβ/δ agonist-GW0724 (1 μmol/L or 10 μmol/L) or the antagonist-GSK3787 (25 μmol/L). We identified 117 differentially expressed genes after treatment with LPS; 102 and 97 differentially expressed genes after treatment respectively with the PPARβ/δ agonist at a concentration of 1 μmol/L or 10 μmol/L, as well as 88-after treatment with the PPARβ/δ antagonist

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