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E-MTAB-3242

ABSTRACT: Transcription profiling by array of spontaneous thymic lymphomas of Lck-MyrAkt positive mice with wild type or knocked-down mTOR expression

PROVIDER: E-MTAB-3242 | ExpressionAtlas | 2015-01-17

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-3242-analysis-methods.tsv	Tabular
	E-MTAB-3242-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-3242-configuration.xml	Xml
	E-MTAB-3242-percentile-ranks.tsv	Tabular
	E-MTAB-3242.condensed-sdrf.tsv	Tabular

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Expression data from thymic lymphomas of Lck-MyrAkt positive mice with WT or KD mTOR expression

Project description:Lck-MyrAkt2 mice develop spontaneous thymic lymphomas at approximately 100-200 days of age, driven in part by a consitutatively-active AKT (due to myristoylation). mTOR Knock Down mice were crossed with Lck-MyrAkt postive mice to model the affects of decreasing mTOR activity on tumors with an activated PI3K/AKT/MTOR pathway. Lck-Akt/mTOR KD mice had prolonged survival compared to the Lck-Akt/mTOR WT mice. We used microarrays to compare the transcriptome in thymic lymphomas between Lck-Akt positive, mTOR WT and Lck-Akt positive, mTOR KD mice. Four thymic lymphomas from Lck-Akt/mTOR WT mice were compared to three thymic lymphomas from Lck-Akt/mTOR KD mice.

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