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E-MTAB-4507

ABSTRACT: Transcription profiling of chicken liver after alpha- and gamma-tocopherol supplementation in case of increased oxidative stress susceptibility

PROVIDER: E-MTAB-4507 | ExpressionAtlas | 2016-03-01

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-4507-analysis-methods.tsv	Tabular
	E-MTAB-4507-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-4507-configuration.xml	Xml
	E-MTAB-4507-percentile-ranks.tsv	Tabular
	E-MTAB-4507.condensed-sdrf.tsv	Tabular

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Transcription profiling of chicken liver after alpha- and gamma-tocopherol supplementation in case of increased oxidative stress susceptibility

Project description:A 30-day nutritional trial in broiler chickens (Ross 308) was conducted to investigate how specific forms of vitamin E (Î±- and Î³-tocopherol) and their combination impact liver gene expression when oxidative susceptibility of the organism is induced by high n-3 polyunsaturated fatty acids (PUFA) intake. Thirty-six one-day-old male broilers were fed a diet enriched with 5 % linseed oil to induce oxidative susceptibility. Beside negative (N) and positive (P) control group, experimental groups were supplemented with either: 67 mg/kg RRR-Î±-tocopherol (A), 67 mg/kg RRR-Î³-tocopherol (G) or with combination of 33.5 mg/kg of each tocopherol (S). Whole chicken genome microarray analysis was performed on liver RNA and selected differentially expressed genes were confirmed by qRT-PCR.

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Hepatocyte-specific knockout of Nicotinamide phosphoribosyltransferase increases susceptibility for liver fibrosis in mice

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