E-MTAB-5054
Ontology highlight
ABSTRACT:
PROVIDER: E-MTAB-5054 | ExpressionAtlas | 2025-01-23
REPOSITORIES: ExpressionAtlas
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| E-MTAB-5054-analysis-methods.tsv | Tabular | |||
| E-MTAB-5054-atlasExperimentSummary.Rdata | Rdata | |||
| E-MTAB-5054-configuration.xml | Xml | |||
| E-MTAB-5054-percentile-ranks.tsv | Tabular | |||
| E-MTAB-5054.condensed-sdrf.tsv | Tabular |
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Project description:In recent years there is a growing epidemiological indication of excess risk of cardiovascular disease at low doses of ionizing radiation without a clear-cut threshold. It is proposed that damage to the vascular endothelium is critical in radiation-related cardiovascular diseases. In order to identify and better understand the underlying molecular mechanisms of high LET (Fe ions) and low LET (X-ray) radiation on endothelial cells, we performed a microarray analysis on immortalized human coronary artery endothelial cells irradiated with 2.00 Gy and compared them with sham-irradiated samples. RNA was extracted at different time points after irradiation (1 day, 7 days).
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