Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-5704

ABSTRACT: Transcription controls growth, cell kinetics and cholesterol supply to sustain ACTH responses.

PROVIDER: E-MTAB-5704 | ExpressionAtlas | 2017-06-15

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-5704-analysis-methods.tsv	Tabular
	E-MTAB-5704-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-5704-configuration.xml	Xml
	E-MTAB-5704-percentile-ranks.tsv	Tabular
	E-MTAB-5704.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 39

Similar Datasets

Project description:Transcription Factor Foxo1 Controls Memory CD8+ T Cell Responses To Infection

| PRJNA203118 | ENA

Mus musculus

Project description:Transcription Factor Foxo1 Controls Memory CD8+ T Cell Responses To Infection [Affymetrix]

| PRJNA203119 | ENA

Mus musculus

Project description:Transcription Factor Foxo1 Controls Memory CD8+ T Cell Responses To Infection [ChIP-Seq]

| PRJNA203120 | ENA

[E-MTAB-131] Estrogen Receptor alpha estrogen-responsive binding sites in MCF-7

Project description:We performed chromatin immunoprecipitation (ChIP) with two polyclonal anti-ERalpha antibodies directed against the N- and C-terminus of the protein, with or without estrogen treatment for 45 minutes of MCF-7 cells, and the immunoprecipitated DNA was sequenced with the Illumina/Solexa Genome Analyzer. ArrayExpress Release Date: 2009-07-27 Publication Title: Estrogen receptor alpha controls a gene network in luminal-like breast cancer cells comprising multiple transcription factors and microRNAs. Publication Author List: Cicatiello L, Mutarelli M, Grober OM, Paris O, Ferraro L, Ravo M, Tarallo R, Luo S, Schroth GP, Seifert M, Zinser C, Chiusano ML, Traini A, De Bortoli M, Weisz A. Person Roles: submitter Person Last Name: Mutarelli Person First Name: Margherita Person Mid Initials: Person Email: mutarelli@tigem.it Person Phone: Person Address: Person Affiliation: Person Roles: investigator Person Last Name: Weisz Person First Name: Alessandro Person Mid Initials: Person Email: alessandro.weisz@unina2.it Person Phone: Person Address: Person Affiliation:

2011-02-05 | GSE25684 | GEO

Hepatocyte nuclear factor 1a controls the proliferation of pancreatic beta-cells by regulating the expression of a Golgi-associated protein

Project description:HNF1A gene encodes a transcription factor hepatocyte nuclear factor 1Î± (HNF1Î±), and mutations in this gene cause maturity-onset diabetes of the young type 3 (MODY3), which is characterized by impaired insulin secretion. Previous studies have shown that HNF1Î± controls the proliferation and number of pancreatic Î²-cells. However, the molecular mechanism by which HNF1Î± regulates Î²-cell growth remains unclear. Here, we demonstrate that TMED6 (transmembrane p24 trafficking protein 6), a transmembrane protein involved in transport processes at the ER-Golgi interface, is a novel HNF1Î± target in pancreatic Î²-cells. TMED6 expression was decreased in the Î²-cells of Hnf1a knockout (KO) mice. Suppressing TMED6 in mouse MIN6 Î²-cells reduced cell growth. Conversely, overexpression of TMED6 rescued the proliferation of Hnf1a knockdown (KD) MIN6 cells. Furthermore, TMED6 KO mice fed a high-fat diet exhibited reduced Î²-cell mass and impaired insulin secretion. Biochemical studies revealed that TMED6 controls Î²-cell proliferation by regulating the proteasomal degradation of GOLGA2, a Golgi-associated protein that regulates cell proliferation. Overexpression of GOLGA2 restored proliferation in both Hnf1a KD and Tmed6 KD MIN6 cells. Taken together, our results indicate that HNF1Î± controls pancreatic Î²-cell proliferation via the TMED6-GOLGA2 axis. We performed proteome analyses of control and Tmed6 KD MIN6 cells in triplicate.

2026-07-09 | PXD065932 | JPOST Repository

[E-MTAB-460] Sanger_zebrafish_sequencing

Project description:Abstract: Paired-end sequence data has been generated using polyA selected RNA from a range of zebrafish tissues using the Illumina Genome Analyzer. Study description: Zebrafish total RNA was extracted from adult tissue, then polyA selected. After fragmentation and reverse transcription Illumina sequencing libraries were prepared. Paired-end sequence runs were performed with 76 base reads on the Illumina Genome Analyzer. ArrayExpress Release Date: 2011-01-28 Person Roles: submitter Person Last Name: Service Person First Name: Submission Person Mid Initials: Person Email: datahose@sanger.ac.uk Person Phone: Person Address: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SA, United Kingdom Person Affiliation: Wellcome Trust Sanger Institute

2011-07-14 | GSE30608 | GEO

sp1Dme

Project description:The evolutionary conserved transcription factor Sp1 controls appendage growth through Notch signaling

| PRJEB14788 | ENA

[E-MTAB-587] PCR_artifacts

Project description:WARNING: This library was yield low amount of material and it was over-amplified by PCR. This libraries are used study the robustness of several statitical methods against PCR artifacts. ChIP experiments were performed on Arabidopsis wildtype inflorescences using an antibody raised against a C-terminal peptide of SEP3. ArrayExpress Release Date: 2011-04-27 Publication Title: ChIP-seq Analysis in R (CSAR): An R package for the statistical detection of protein-bound genomic regions Publication Author List: Jose M. Muino, Kerstin Kaufmann, Roeland C. H. J. van Ham, Gerco C. Angenent, and Pawel Krajewski Person Roles: submitter Person Last Name: Muino Person First Name: Jose Person Mid Initials: M. Person Email: jose.muino@wur.nl Person Phone: 0317-481122 Person Address: Droevendaalsesteeg 1, P.O. Box 16, 6700 AA Wageningen, The Netherlands Person Affiliation: Plant Research International B.V.

2011-07-14 | GSE30616 | GEO

Fusion transcription factor dosage controls cell state in rhabdomyosarcoma

Project description:Fusion transcription factor dosage controls cell state in rhabdomyosarcoma

| PRJNA1365233 | ENA

Fusion transcription factor dosage controls cell state in rhabdomyosarcoma

Project description:Fusion transcription factor dosage controls cell state in rhabdomyosarcoma

| PRJNA1365234 | ENA