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E-MTAB-5974

ABSTRACT: RNA-seq of muscle in mice with Lewis lung carcinoma with or without access to physical activity

PROVIDER: E-MTAB-5974 | ExpressionAtlas | 2019-05-14

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-5974-analysis-methods.tsv	Tabular
	E-MTAB-5974-analytics.tsv	Tabular
	E-MTAB-5974-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-5974-configuration.xml	Xml
	E-MTAB-5974-g2_g1-mvaPlot.png	Other

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E-MTAB-5311

Project description:RNA-seq of Lewis lung carcinoma tumors in mice with or without exercise

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RNA-seq of muscle in mice with Lewis lung carcinoma with or without access to physical activity

Project description:RNA-seq of muscle in mice with Lewis lung carcinoma with or without access to physical activity

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RNA-seq of muscle in mice with Lewis lung carcinoma with or without access to physical activity

Project description:Exercise has been correlated with prevention of weight loss (cachexia) attributed to tumor initiation and progression. However, it is unclear what are the molecular mechanisms behind this beneficial effect of exercise to prevent cachexia. In this study, we obtained RNA-seq data from biopsies of muscle in 24 mice with Lewis lung carcinoma that reached 1 cm3 volume, 14 with access to running wheel and 10 without (controls).

2019-08-14 | E-MTAB-5974 | biostudies-arrayexpress

RNA-seq of Lewis lung carcinoma tumors in mice with or without exercise

Project description:Exercise has been correlated with retardation of tumor initiation and progression. However, it is unclear what are the molecular mechanisms behind this beneficial effect of exercise. In this study, we obtained RNA-seq data from biopsies of Lewis lung carcinoma tumors in a total of 16 mice, 8 with access to running wheel and 8 without (controls).

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miRNA expression in myeloid-derived suppressor cells (MDSCs) treated with or without whole ?-glucan particles (WGP)

Project description:Murine MDSCs isolated from the spleens of Lewis lung carcinoma mice were treated with or without WGP, and then miRNA array was used to analyze the differentailly expressed miRNAs. Murine MDSCs were isolated from the spleens of Lewis lung carcinoma tumor-bearing mice, and the sorted MDSCs were stimulated with or without 100 µg/ml WGP for 24 h. Then, the total RNA was extracted to perform miRNA array to analyze the differentially expressed miRNAs in MDSCs treated with or without WGP

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miRNA expression in myeloid-derived suppressor cells (MDSCs) treated with or without whole β-glucan particles (WGP)

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E-GEOD-81089

Project description:RNA-seq of 199 non-small cell lung carcinoma patients and 19 paired normal lung tissues

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RNA-seq of Lewis lung carcinoma tumors in mice with or without exercise

Project description:RNA-seq of Lewis lung carcinoma tumors in mice with or without exercise

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Whole transcriptome of Lewis lung carcinoma cells of Mus musculus

Project description:Purpose: To study the alteration of whole transcriptome of Lewis lung carcinoma (LLC) cells after the decreasing of malignant properties of tumor by treatment of tumor-bearing mice with RNase A. Methods: Whole transcriptome profile of Lewis lung carcinoma before and after RNase A treatment were generated by deep sequencing using SOLiD 5.5. The sequence reads were mapped by Bioscope 1.3 software, differential expression was evaluated by Cufflinks v.2.0.1 package. Results: Difference in expression was found for 966 genes. Conclusions: Our study represents the first detailed analysis of alteration of transcriptome of Lewis lung carcinoma after the decrease of malignant prtoperties of the tumor (proliferation and invasion) by RNase A. Whole transcriptome profile of Lewis lung carcinoma before and after RNase A treatment were generated by deep sequencing using SOLiD 5.5.

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