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E-MTAB-6909

ABSTRACT: Transcription profiling by array of Apc-deficient proximal colonic epithelium upon Msx1 transcription factor depletion

PROVIDER: E-MTAB-6909 | ExpressionAtlas | 2018-09-17

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-MTAB-6909-analysis-methods.tsv	Tabular
	E-MTAB-6909-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-6909-configuration.xml	Xml
	E-MTAB-6909-percentile-ranks.tsv	Tabular
	E-MTAB-6909.condensed-sdrf.tsv	Tabular

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Transcription profiling by array of Apc-deficient proximal colonic epithelium upon Msx1 transcription factor depletion

Project description:The first step in the development of human colorectal cancer (CRC) is the aberrant hyperactivation of the Wnt signaling pathway, predominantly caused by inactivating mutations in the adenomatous polyposis coli (APC) gene which encodes an essential tumor suppressor. In order to identify genes affected by Apc loss, expression profiling of intestinal epithelium isolated from mice harboring the conditional allele of the gene was performed. The gene encoding transcriptional factor msh homeobox 1 (Msx1) displayed robust upregulation upon Apc inactivation. To characterize the gene signature in colon upon Msx1 depletion, colonic epithelium from mice harboring conditional alleles of Apc and Msx1 was isolated and the gene expression profile was compared with control mice harboring the conditional allele of Apc only.

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