Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-7428

ABSTRACT: SUMOylation promotes survival and integration of neural stem cell grafts in stroke

PROVIDER: E-MTAB-7428 | ExpressionAtlas | 2019-01-16

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-7428-analysis-methods.tsv	Tabular
	E-MTAB-7428-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-7428-configuration.xml	Xml
	E-MTAB-7428-percentile-ranks.tsv	Tabular
	E-MTAB-7428.condensed-sdrf.tsv	Tabular

Items per page:

1 - 5 of 121

Similar Datasets

E-MTAB-3013

Project description:Transcription profiling by array of adult mouse neural stem cell differentiation after 3 and 12 hours of fibrinogen treatment

2014-10-15 | E-MTAB-3013 | ExpressionAtlas

E-MTAB-3419

Project description:Control and Bmi1-overexpressing adult murine neural stem cells

2015-03-18 | E-MTAB-3419 | ExpressionAtlas

E-GEOD-48522

Project description:Akt signalling leads to stem cell activation and promotes tumour development in epidermis.

2015-07-16 | E-GEOD-48522 | ExpressionAtlas

E-GEOD-45278

Project description:Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo [RNA-seq]

2016-05-13 | E-GEOD-45278 | ExpressionAtlas

E-MTAB-3864

Project description:Expression profiling of normal and glioblastoma-derived neural stem cells

2025-01-23 | E-MTAB-3864 | ExpressionAtlas

E-GEOD-50059

Project description:Endothelin2 signaling in the neural retina promotes the endothelial tip cell state and inhibits angiogenesis

2015-07-27 | E-GEOD-50059 | ExpressionAtlas

E-GEOD-58475

Project description:Transcription profiling by array of Nurr1 gene expression in human neural stem cell lines

2025-01-24 | E-GEOD-58475 | ExpressionAtlas

E-MTAB-6681

Project description:RNA-seq of Glioma Neural Stem (GNS) cell line G144 after MEK inhibition in wild type (WT) and CIC (Capicua) depleted cells.

2025-01-23 | E-MTAB-6681 | ExpressionAtlas

Interaction between subventricular zone microglia and neural stem cells impacts the neurogenic response in a mouse model of cortical ischemic stroke

Project description:After a stroke, the neurogenic response from the subventricular zone (SVZ) to repair the brain is limited. Microglia, as an integral part of the distinctive SVZ microenvironment, control neural stem / precursor cell (NSPC) behavior. Here, we show that discrete stroke-associated SVZ microglial clusters negatively impact the innate neurogenic response, and we propose a repository of relevant microglia–NSPC ligand–receptor pairs. After photothrombosis, a mouse model of ischemic stroke, the altered SVZ niche environment leads to immediate activation of microglia in the niche and an abnormal neurogenic response, with cell-cycle arrest of neural stem cells and neuroblast cell death. Pharmacological restoration of the niche environment increases the SVZ-derived neurogenic repair and microglial depletion increases the formation and survival of newborn neuroblasts in the SVZ. Therefore, we propose that altered cross-communication between microglial subclusters and NSPCs regulates the extent of the innate neurogenic repair response in the SVZ after stroke.

2024-09-02 | GSE275939 | GEO

Therapeutic use of R-spondins to augment the cerebrovascular and neuronal Wnt signaling and improve stroke outcome in mice [scRNA-Seq]

Project description:Wnt signaling is critical for blood-brain barrier function, neuronal survival and adult neurogenesis, yet Wnt proteins are poorly suited as therapeutics for stroke due to production and pharmacokinetic challenges. Here, we show that R-spondins (RSPOs), a family of easily produced and secreted proteins capable of robustly augmenting Wnt signaling, are widely expressed in adult mouse brain and upregulated upon ischemia and reperfusion injury. Neutralizing endogenous RSPOs with the soluble ectodomains of their membrane receptors LGR5, ZNRF3 and RNF43 increased cerebral infarction in a murine stroke model. Conversely, systemic administration of RSPOs substantially reduced cerebral infarction and improved neurological outcomes. The neuroprotective effects of RSPOs were dependent on LGR4/ZNRF3-mediated augmentation of canonical Wnt/-catenin signaling in endothelial and neuronal cells, which in turn promoted blood-brain barrier integrity, neuronal PDGF-CC expression and survival. Further, RSPOs promotes the proliferation and expansion of neural stem/progenitor cells and post-stroke neurogenesis. Thus, we identify a previously unknown neuroprotective and pro-neurogenic mechanism and describe the therapeutic potential of recombinant RSPOs in ischemic stroke.

2023-10-07 | GSE159454 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data