Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

E-MTAB-7836

ABSTRACT: Gene-expression changes in neurons active during contextual fear conditioning compared to controls left in the homecage

PROVIDER: E-MTAB-7836 | ExpressionAtlas | 2019-09-09

REPOSITORIES: ExpressionAtlas

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	E-MTAB-7836-analysis-methods.tsv	Tabular
	E-MTAB-7836-analytics.tsv	Tabular
	E-MTAB-7836-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-7836-configuration.xml	Xml
	E-MTAB-7836-g2_g1-mvaPlot.png	Other

Items per page:

1 - 5 of 22

Similar Datasets

Gene-expression changes in neurons active during contextual fear conditioning compared to controls left in the homecage

Project description:Gene-expression changes in neurons active during contextual fear conditioning compared to controls left in the homecage

| PRJEB31967 | ENA

E-MTAB-6460

Project description:RNA-seq of heart left ventricle during myocardial ischemia in TAB-1 knock-in mice compared to wild type controls

2018-09-17 | E-MTAB-6460 | ExpressionAtlas

Gene-expression changes in neurons active during contextual fear conditioning compared to controls left in the homecage

Project description:This experiment uses a transgenic mouse that allows for activity-induced expression of an HA-tagged ribosome in an inducible and cre-dependent manner. This allowed us to assess long-lasting gene-expression changes in neurons active during contextual fear conditioning. Previous studies have used similar systems to look a transient changes in gene expression in these neurons, but we developed a system to look at long lasting changes. The workflow includes tissue dissection of the prefrontal cortex, tissue homogenization followed by an immunoprecipitation of the tagged ribosomes using antibodies against HA. RNA bound to the ribosomes is then purified, a cDNA library is prepared and RNAseq was performed. The experimental group was fear conditioned and the control group was left in their homecage for induction of HA- expression in active neurons.

2020-03-27 | E-MTAB-7836 | biostudies-arrayexpress

E-MTAB-8299

Project description:RNAseq analysis in TNF treated HUVEC cells compared to controls

2025-01-16 | E-MTAB-8299 | ExpressionAtlas

E-GEOD-20489

Project description:Microarray characterization of gene expression changes in blood during acute ethanol exposure

2025-01-24 | E-GEOD-20489 | ExpressionAtlas

E-MTAB-5086

Project description:Microarray comparing gene expression changes between control, normoglycaemic mice, and mice expressing the human neonatal diabetes mutation Kir6.2-V59M in pancreatic beta-cells left diabetic for 2 weeks

2016-10-13 | E-MTAB-5086 | ExpressionAtlas

E-GEOD-55098

Project description:Expression data from peripheral blood mononuclear cell in patients with type 1 diabetes compared with normal controls

2025-01-24 | E-GEOD-55098 | ExpressionAtlas

E-MEXP-3497

Project description:Transcription profiling by array of bovine gene expression changes during inflammatory gamma-herpesvirus infection

2015-10-22 | E-MEXP-3497 | ExpressionAtlas

E-MTAB-9850

Project description:Temporal transcriptomic changes during DSS colitis development and resolution.

2020-12-09 | E-MTAB-9850 | ExpressionAtlas

Optogenetic Stimulation of Prelimbic Pyramidal Neurons Maintains Fear Memories and Modulates Amygdala Pyramidal Neuron Transcriptome

Project description:The suppression of fear memory in the absence of danger (fear extinction) requires coordinated neural activity within the amygdala and medial prefrontal (prelimbic and infralimbic) cortex. Any behavior has a transcriptomic signature that is modified by environmental experiences, and specific genes are involved in functional plasticity and synaptic wiring during fear memory and extinction. In the present study, we investigated the effects of optogenetic manipulations of prelimbic pyramidal neurons on amygdala gene expression to analyze the specific transcriptional pathways involved in fear extinction. To this aim, transgenic mice (Thy1-COP4) having cortical and amygdala pyramidal neurons optogenetically excitable were (or not) fear-conditioned. During the extinction phase, the mice received optogenetic (or sham) stimulations to maintain the activation of the prelimbic pyramidal neurons and impair fear extinction. At the end of behavioral testing, electrophysiological (Excitatory Post-Synaptic Currents) and morphological (spinogenesis) correlates were evaluated in the pyramidal neurons of prelimbic cortex. Furthermore, transcriptomic cell-specific RNA-analyses (differential gene expression profiling and functional enrichment analyses) were performed in amygdala pyramidal neurons. Results demonstrate that pyramidal neurons of prelimbic cortex are involved in modulation of the fear responses during extinction phase and their optogenetic stimulation in fear-conditioned mice results in strong modifications of the amygdala transcriptome. Understanding the transcriptomic architecture of fear extinction may facilitate the comprehension of fear-related disorders.

2021-01-14 | GSE162417 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data