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E-MTAB-8515

ABSTRACT: RNA-seq of purified cardiomocytes from adult mice (+/- AAV-CCNT1) 4 hours post MycER activation compared controls.

PROVIDER: E-MTAB-8515 | ExpressionAtlas | 2020-01-13

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-8515-analysis-methods.tsv	Tabular
	E-MTAB-8515-analytics.tsv	Tabular
	E-MTAB-8515-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-8515-configuration.xml	Xml
	E-MTAB-8515-g1_g2-mvaPlot.png	Other

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RNA-seq of purified cardiomocytes from adult mice (+/- AAV-CCNT1) 4 hours post MycER activation compared controls.

Project description:RNA-seq of purified cardiomocytes from adult mice (+/- AAV-CCNT1) 4 hours post MycER activation compared controls.

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RNA-seq of heart from adult mice 4 and 48 hours post MycER activation compared controls

Project description:RNA-seq of heart from adult mice 4 and 48 hours post MycER activation compared controls

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RNA-seq of tissue from adult mice 4 hours post MycER activation compared to wild type controls.

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RNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.

Project description:RNA-seq of heart tissue from 15 day old mice 4 hours post MycER activation compared to wild type controls. RNA-seq of heart tissues from adult mice that have expressed oncogenic H-Ras for 4 weeks followed by MycER activation for 4 hours compared to MycER negative controls.

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Early cell specific transcriptional changes during compensatory renal hypertrophy

Project description:The mechanism driving the remarkable ability of the remaining kidney to enlarge and increase its function following the removal of its contralateral pair remains elusive. To explore the pathways driving compensatory renal hypertrophy, comprehensive RNA-seq transcriptional studies were undertaken in the kidneys of C57BL/6 mice undergoing hypertrophy at 24, 48, and 72 hours following nephrectomy, and these results were compared with mice undergoing sham operations. In addition, mass spectrometry was carried out at 24 hours to examine changes in protein expression. Single-nuclei RNA-Seq was used to delineate bulk RNA-seq data into cell types at 24 hours post-nephrectomy. HK-2 renal tubular cells were examined for their ability to undergo hypertrophy in the presence of IGF-1 via the activation of cholesterol biosynthesis pathways. Bulk RNA-seq revealed substantial time-dependent enhancement of cholesterol biosynthesis pathways, increases in mitochondrial gene expression, and cell cycle perturbations. Single-nuclei RNA-Seq at 24 hours post-nephrectomy showed that Sterol Binding Protein 2 (SREBP2) activity increases in medullary thick ascending limb cells and, to a lesser extent, in proximal tubular cells, consistent with the role of promoting cholesterol synthesis. Furthermore, SREBP2 was found to regulate cell size following IGF-1 stimulation in HK-2 cells. There are early, cell-specific alterations in gene expression of cholesterol biosynthesis pathways, mitochondrial genes, and the cell cycle in kidneys undergoing compensatory hypertrophy. SREBP2 activity in the medullary thick ascending limb and, to a lesser extent, in proximal tubules may play a previously undescribed role in promoting cholesterol metabolism in the mechanism underlying compensatory renal hypertrophy.

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E-MTAB-7595

2019-08-07 | E-MTAB-7595 | ExpressionAtlas

Genome wide assessment of gene expression in alpha and beta cells from lean and obese mice

Project description:We report the assessment of transcriptome by RNA-Seq of FACS purified Ins1-H2bmCherry purified primary mouse beta cells and Gcg-CreERT2 x YFP positive alpha cells of obese (ob/ob) mice compared to lean littermate controls

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RNA-seq of tissue from adult mice 4 hours post MycER activation compared to wild type controls.

Project description:Aim: To determine RNA expression levels in various tissues of mice 4 hours post Myc activation. Tissues were isolated from adult wild-type (R26+/+) and R26CAG-c-MycERT2/+ mice following 4 hours of MycER activation via administration of (Z)-4-hydroxytamoxifen.

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RNA-seq of heart from adult mice 4 and 48 hours post MycER activation compared controls

Project description:Aim: To determine RNA expression levels in heart tissues of mice 4 and 48 hours post Myc activation. Mice were systemically infected with a cardiomyocyte specific adeno associated virus (AAV9) at 4 to 6 weeks of age. Hearts were isolated from adult mice that had been infected with AAV9-Ccnt1 and were either Myh6-cre;R26CAG-c-MycERT2/+ or R26CAG-c-MycERT2/+ following 4 hours of MycER activation via administration of (Z)-4-hydroxytamoxifen. Hearts were isolated from adult mice that had been infected with either AAV9-Ccnt1 or AAV9-RFP and were R26CAG-c-MycERT2/+ 48 hours post a single injection of tamoxifen to induce MycER activity.

2020-02-24 | E-MTAB-8462 | biostudies-arrayexpress

Project description:Aim: To determine RNA expression levels in the heart of mice 4 hours post Myc activation. Hearts were isolated from 15 day old wild-type (R26+/+) and R26CAG-c-MycERT2/+ mice following 4 hours of MycER activation via administration of (Z)-4-hydroxytamoxifen. Hearts were isolated from adult TetO-HRas; Myh6-tTA; R26CAG-c-MycERT2/+ and TetO-HRas; Myh6-tTA following 4 weeks of oncogenic H-Ras activation (Doxycycline withdrawal) and following 4 hours of MycER activation via administration of (Z)-4-hydroxytamoxifen.

2020-02-24 | E-MTAB-7595 | biostudies-arrayexpress

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