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E-MTAB-9184

ABSTRACT: RNAseq of colon intestinal epithelium extracted from mice infected with Citrobacter rodentium

PROVIDER: E-MTAB-9184 | ExpressionAtlas | 2023-06-16

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-9184-analysis-methods.tsv	Tabular
	E-MTAB-9184-analytics.tsv	Tabular
	E-MTAB-9184-apply_fixes_zooma_mappings.done	Other
	E-MTAB-9184-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-9184-configuration.xml	Xml

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RNAseq of colon intestinal epithelium extracted from mice infected with Citrobacter rodentium

Project description:RNAseq of colon intestinal epithelium extracted from mice infected with Citrobacter rodentium

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RNAseq of colon intestinal epithelium extracted from mice infected with Citrobacter rodentium

Project description:The intestinal epithelium is our first line of defense against infections of the gut and the plasticity in cellular differentiation of the intestinal epithelium is an important part of this response. Here we sequenced the colon intestinal epithelium from mice infected with Citrobacter rodentium to determine how the intestinal epithelium adapts in the context of an infection. By comparing these data to small intestinal organoids treated with cytokines (see related accessions) we determine that the intestinal epithelial response to C. rodentium infection correspond to a type III infection driven by IL22.

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E-MTAB-9183

Project description:RNAseq of small intestinal epithelium extracted from mice infected with Nippostrongylus brasiliensis

2023-06-16 | E-MTAB-9183 | ExpressionAtlas

Differential gene expression in colon organoids isolated from germ-free, E.coli strains Nissle 1917 and O6K13 monoassociated, and conventionally reared mice

Project description:Commensal microbiota contribute to gut homeostasis and influence gene expression. Intestinal organoid culture closely represent intestinal epithelium and retain intestinal stem cells and dynamic recovery capabilities as well as all major cell types of the intestinal epithelium. We established organoid culture using colon crypts isolated from germ-free (GF), and gnotobiotic mice monocolonized either with the E.coli strain O6K13 (O) or Nissle 1917 strain (N). The expression profiles of these organoids were compared to the organoid culture isolated from conventionally reared (CR) mice in order to disclose genes differentially expressed in response to the change in the intestinal microflora composition.

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