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E-MTAB-9187

ABSTRACT: Transcription profiling by array of Apc+/Delta716 mouse intestinal polyps vs normal intestinal mucosa

PROVIDER: E-MTAB-9187 | ExpressionAtlas | 2020-06-16

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-MTAB-9187-analysis-methods.tsv	Tabular
	E-MTAB-9187-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-9187-configuration.xml	Xml
	E-MTAB-9187-percentile-ranks.tsv	Tabular
	E-MTAB-9187.condensed-sdrf.tsv	Tabular

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Transcription profiling by array of Apc+/Delta716 mouse intestinal polyps vs normal intestinal mucosa

Project description:The APC (Adenomatous Polyposis Coli) gene encodes a large multidomain protein that plays an integral role in the Wnt/beta-catenin signaling pathway. The loss-of-function mutation in APC is considered the earliest genetic alteration in the course of adenoma-carcinoma sequence of colorectal cancer progression, and the resulting constitutive activation of Wnt/beta-catenin signaling is required for the maintenance of advanced colorectal cancer. In order to identify genes affected by loss of Apc function, we performed transcription profiling of mouse small intestinal tissues comparing polyps with normal mucosa of Apc+/Delta716 mice. We isolated total RNA from intestinal polyps and normal intestinal mucosa from 3 individual Apc+/Delta716 mice. Total RNA samples were then employed to perform microarray analysis (Agilent Whole Mouse Genome Microarray Ver. 2.0, 4x44K).

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