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E-MTAB-9362

ABSTRACT: LXR mediated-signalling protects human hair follicles against doxorubicin-induced toxicity ex vivo

PROVIDER: E-MTAB-9362 | ExpressionAtlas | 2025-01-23

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-9362-analysis-methods.tsv	Tabular
	E-MTAB-9362-analytics.tsv	Tabular
	E-MTAB-9362-apply_fixes_zooma_mappings.done	Other
	E-MTAB-9362-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-9362-configuration.xml	Xml

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LXR mediated-signalling protects human hair follicles against doxorubicin-induced toxicity ex vivo

Project description:LXR mediated-signalling protects human hair follicles against doxorubicin-induced toxicity ex vivo

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LXR mediated-signalling protects human hair follicles against doxorubicin-induced toxicity ex vivo

Project description:Although chemotherapy-induced alopecia (CIA) is one of the most distressing adverse effects of cancer treatment, there are still no pharmacological interventions available and there remains an urgent unmet need to identify novel targets for therapy. We hypothesized that selected compounds which enhance ABC transporter activity and thus drug efflux from CIA-affected hair follicle (HF) epithelium may award relative protection from chemotherapy-induced HF toxicity. We found that the LXR agonist T0901317 significantly increased cell survival, attenuated LDH release, caspase-3 activity and DNA double strand breaks (DSBs) in doxorubicin (DOX)-treated outer root sheath keratinocytes (ORS-KCs) in vitro and protected human HFs from DOX-induced apoptosis ex vivo. RNA sequencing was performed to investigate the potential mechanism(s) by which T0901317 may protect against DOX-induced cell survival and apoptosis of ORS-KC.

2021-02-19 | E-MTAB-9362 | biostudies-arrayexpress

Hair follicles engage in chemosensation: Olfactory receptor OR2AT4 regulates human hair growth

Project description:Olfactory receptors (OR) regulate physiological cell functions beyond olfaction. Here, we show that human hair follicle (HF) epithelium engages in chemosensation: it expresses OR2AT4, whose stimulation by a synthetic sandalwood odorant (prolongs hair growth (anagen) ex vivo via increased IGF-1 production. Instead, OR2AT4-silencing inhibits hair growth. Thus, human HFs can “smell” and require OR2AT4-mediated signaling to sustain their growth, inviting novel therapeutic hair growth regulation by targeting HF chemosensation.

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Project description:Cardiac toxicity induced by doxorubicin

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Project description:Mitochondrial superoxide-mediated mitohormesis protects against doxorubicin-induced cardiotoxicity [6Week_RNAseq]

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