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E-MTAB-9392

ABSTRACT: Role of Macrophage migration inhibitory factor (MIF) in pancreatic stellate cells (PSCs)

PROVIDER: E-MTAB-9392 | ExpressionAtlas | 2023-06-16

REPOSITORIES: ExpressionAtlas

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			Action	DRS
	E-MTAB-9392-analysis-methods.tsv	Tabular
	E-MTAB-9392-analytics.tsv	Tabular
	E-MTAB-9392-apply_fixes_zooma_mappings.done	Other
	E-MTAB-9392-atlasExperimentSummary.Rdata	Rdata
	E-MTAB-9392-configuration.xml	Xml

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Role of Macrophage migration inhibitory factor (MIF) in pancreatic stellate cells (PSCs)

Project description:The presence of activated pancreatic stellate cells (PSCs) in the pancreatic ductal adenocarcinoma (PDAC) microenvironment plays a significant role in cancer progression. Macrophage migration inhibitory factor (MIF) is overexpressed in PDAC tissues and expressed by both cancer and stromal cells. The expression status of MIF and its receptors in PDAC- associated fibroblasts or PSCs and its pathophysiological roles are yet to be elucidated. The next-generation sequencing technique was adapted to check the effect of MIF absence on the expression of other genes in mice (mPSCs).

2022-09-28 | E-MTAB-9392 | biostudies-arrayexpress

Role of Macrophage migration inhibitory factor (MIF) in pancreatic stellate cells (PSCs)

Project description:Role of Macrophage migration inhibitory factor (MIF) in pancreatic stellate cells (PSCs)

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Pancreatic cancer exosomes induce pre-metastatic niche formation in the liver

Project description:Pancreatic cancers (PCs) are highly metastatic with poor prognosis, mainly due to delayed detection. We hypothesized that intercellular communication is critical for metastatic progression. Here, we show that PC-derived exosomes induce liver pre-metastatic niche formation in naïve mice and consequently increase liver metastatic burden. Uptake of PC-derived exosomes by Kupffer cells caused transforming growth factor β secretion and upregulation of fibronectin production by hepatic stellate cells. This fibrotic microenvironment enhanced recruitment of bone marrow-derived macrophages. We found that macrophage migration inhibitory factor (MIF) was highly expressed in PC-derived exosomes, and its blockade prevented liver pre-metastatic niche formation and metastasis. Compared to patients whose pancreatic tumors did not progress, MIF was markedly higher in exosomes from stage I PC patients who later developed liver metastasis. These findings suggest that exosomal MIF primes the liver for metastasis and may be a prognostic marker for the development of PC liver metastasis.

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Transcription profiling of wounds from ovariectomized MIF null mice and controls to investigate the role of MIF during wound healing using BALB/C MIF null mice

Project description:The aim of this experiment was to investigate the role of MIF during wound healing using BALB/C MIF null mice and in the context of reduced estrogen-associated impaired healing using ovariectomized mice (a mouse model of age-associated delayed healing). Ageing is associated with delayed cutaneous wound healing resulting from reduced estrogen levels. Macrophage migration inhibitory factor (MIF - NCBI RefSeq: NM_010798) is thought to mediate the effects of estrogen on wound healing. Gene expression was compared between wounds from ovariectomized MIF null mice and controls.

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mif-4

Project description:Caenorhabditis elegans mif-4, MIF (Macrophage migration Inhibitory Factor) related [Source:UniProtKB/TrEMBL;Acc:Q9GUG4], is expressed in 1 baseline experiment(s);

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mif-1

Project description:Caenorhabditis elegans mif-1, MIF (Macrophage migration Inhibitory Factor) related [Source:UniProtKB/TrEMBL;Acc:Q9U228], is expressed in 1 baseline experiment(s);

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mif-1

Project description:Caenorhabditis elegans mif-1, MIF (Macrophage migration Inhibitory Factor) related [Source:UniProtKB/TrEMBL;Acc:Q9U228], is differentially expressed in 3 experiment(s);

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Mif

Project description:Rattus norvegicus Mif, macrophage migration inhibitory factor [Source:RGD Symbol;Acc:621163], is differentially expressed in 28 experiment(s);

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Mif

Project description:Rattus norvegicus Mif, macrophage migration inhibitory factor [Source:RGD Symbol;Acc:621163], is expressed in 2 baseline experiment(s);

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MIF

Project description:Sus scrofa MIF, macrophage migration inhibitory factor [Source:VGNC Symbol;Acc:VGNC:90222], is differentially expressed in 3 experiment(s);

| ENSSSCG00000010067 | ExpressionAtlas

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