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E-PROT-105

ABSTRACT: Proteome analysis of formalin-fixed paraffin-embedded colorectal adenomas

PROVIDER: E-PROT-105 | ExpressionAtlas | 2023-06-22

REPOSITORIES: ExpressionAtlas

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Dataset's files

Source:

			Action	DRS
	E-PROT-105-MappedToGeneID.txt	Txt
	E-PROT-105-MaxQuant_Summary_ExpressionAtlas_LabelFree_Rmarkdown.pdf	Pdf
	E-PROT-105-analysis-methods.tsv	Tabular
	E-PROT-105-configuration.xml	Xml
	E-PROT-105-factors.xml	Xml

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Project description:Colorectal adenomas are common precancerous lesions with the potential for malignant transformation to colorectal adenocarcinoma. Endoscopic polypectomy provides an opportunity for cancer prevention, however, recurrence rates are high. We collected formalin-fixed paraffin-embedded tissue of fourteen primary adenomas with recurrence, fourteen primary adenomas without recurrence, and fourteen matched pair samples (primary adenoma and the corresponding recurrent adenoma). These samples were analysed by array-based comparative genomic hybridisation (aCGH) to understand the dynamics of copy number alterations (CNAs) and to identify molecular markers to predict recurrence. ACGH analysis confirmed the genetic landscape specific for colorectal tumorigenesis, i.e., CNAs of chromosomes 7 (13.7%), 13q (13.7%), 18 (5.8%) and 20q (13.7%). CNAs were detected in 41/51 (80.4%) of colorectal adenomas (2N). Focal aberrations (≤10 Mbp) were mapped to chromosome bands 6p22.1-p21.33 (33.3%), 7q22.1 (31.4%) and 16q21 (29.4%). Gains of CDX2 were exclusively seen in adenomas with recurrence compared to adenomas without recurrence. However, the average number of copy alterations failed to discriminate primary adenomas with recurrence from primary adenomas without recurrence.

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