E-PROT-43
Ontology highlight
ABSTRACT:
TISSUE(S): Ovary, Substantia Nigra, Liver, Pancreas
PROVIDER: E-PROT-43 | ExpressionAtlas | 2021-05-20
REPOSITORIES: ExpressionAtlas
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This model is described in the article:
Tissue-based map of the human proteome
Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edllund K, Lundberg E, Navani S, Szigyarto AC, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist P, Berlin H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.
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This model is hosted on
BioModels Database
and identified by:
MODEL1411240032.
To cite BioModels Database, please use:
BioModels:
ten-year anniversary .
To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
CC0
Public Domain Dedication for more information.
2015-01-28 | MODEL1411240032 | BioModels
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This model is described in the article:
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Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edllund K, Lundberg E, Navani S, Szigyarto AC, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist P, Berlin H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.
Science 2015 January; 347(6220)
Abstract:
Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue proteome based on an integrated omics approach that involves quantitative transcriptomics at the tissue and organ level, combined with tissue microarray–based immunohistochemistry, to achieve spatial localization of proteins down to the single-cell level. Our tissue-based analysis detected more than 90% of the putative protein-coding genes. We used this approach to explore the human secretome, the membrane proteome, the druggable proteome, the cancer proteome, and the metabolic functions in 32 different tissues and organs. All the data are integrated in an interactive Web-based database that allows exploration of individual proteins, as well as navigation of global expression patterns, in all major tissues and organs in the human body.
This model is hosted on
BioModels Database
and identified by:
MODEL1411240008.
To cite BioModels Database, please use:
BioModels:
ten-year anniversary .
To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
CC0
Public Domain Dedication for more information.
2015-01-28 | MODEL1411240008 | BioModels