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E-PROT-81

ABSTRACT: The protein expression landscape of the heart across humans and model organisms

TISSUE(S): Left Cardiac Atrium, Heart Right Ventricle, Heart Left Ventricle, Right Cardiac Atrium

PROVIDER: E-PROT-81 | ExpressionAtlas | 2022-01-14

REPOSITORIES: ExpressionAtlas

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Dataset's files

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			Action	DRS
	E-PROT-81-MappedToGeneID.txt	Txt
	E-PROT-81-MaxQuant_Summary_ExpressionAtlas.pdf	Pdf
	E-PROT-81-analysis-methods.tsv	Tabular
	E-PROT-81-apply_fixes_zooma_mappings.done	Other
	E-PROT-81-configuration.xml	Xml

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E-PROT-120

Project description:The protein expression landscape of the heart across humans and model organisms

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Multi-Tissue WGBS Analysis in Mini Pigs: Body Size and Tissue-Specific Comparisons

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Quantitative proteomics of human heart samples collected in vivo reveal the remodeled protein landscape of dilated left atrium without atrial fibrillation.

Project description:Genetic and genomic research has greatly advanced our understanding of heart disease; yet a comprehensive map of the protein landscape of living human hearts is still lacking. Here we set out to identify the molecular basis of functional differences between human cardiac chambers by comprehensive protein expression quantification from samples collected in vivo by high-resolution mass spectrometry. Cardiac biopsies of right atria (RA), left atria (LA) and left ventricle (LV) were obtained from seven humans undergoing open chest surgery and analyzed by high-resolution mass spectrometry. We identify hundreds of proteins with a chamber specific expression pattern, supporting the different functional roles of the cardiac chambers, enabling identification of chamber specific drug targets, and offering novel links between genomic data and the mechanisms of disease.

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E-PROT-62

Project description:Quantitative proteomics of human heart samples collected in vivo reveal the remodeled protein landscape of dilated left atrium without atrial fibrillation.

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Expression data from adult (9 month-old) hearts from GRK2 heterozygous C57BL/6J mice and its wild type littermates

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Expression data from adult (9 month-old) and young (4 month-old) hearts from GRK2 heterozygous C57BL/6J mice.

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Expression data from young (4 month-old) hearts from GRK2 heterozygous C57BL/6J mice and its wild type littermates

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