Transcriptomics,Multiomics

Dataset Information

70

Transcription profiling by array of human lymphocytes from prostate carcinoma patients after X-radiation treatment


ABSTRACT: For a case-control study, we selected 54 prostate carcinoma patients with no evidence of disease 2 years after curative

REANALYSIS of: E-TABM-90

ORGANISM(S): Homo sapiens  

PROVIDER: E-TABM-90 | ExpressionAtlas | 2015-07-29

REPOSITORIES: ExpressionAtlas

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Publications

Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity.

Svensson J Peter JP   Stalpers Lukas J A LJ   Esveldt-van Lange Rebecca E E RE   Franken Nicolaas A P NA   Haveman Jaap J   Klein Binie B   Turesson Ingela I   Vrieling Harry H   Giphart-Gassler Micheline M  

PLoS medicine 20061001 10


BACKGROUND: Radiation is an effective anti-cancer therapy but leads to severe late radiation toxicity in 5%-10% of patients. Assuming that genetic susceptibility impacts this risk, we hypothesized that the cellular response of normal tissue to X-rays could discriminate patients with and without late radiation toxicity. METHODS AND FINDINGS: Prostate carcinoma patients without evidence of cancer 2 y after curative radiotherapy were recruited in the study. Blood samples of 21 patients with severe  ...[more]

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