Extracellular Matrix Protein-1 secretory isoform promotes ovarian cancer through increasing alternative mRNA splicing and stemness

ABSTRACT: Extracellular Matrix Protein-1 (ECM1) promotes tumorigenesis in multiple organs but the mechanisms associated to ECM1 isoform subtypes have yet to be clarified. We report in this study that the secretory ECM1a isoform induces tumorigenesis through the G-P-R motif binding to integrin alpha X/beta 2 and the activation of AKT/FAK/Rho/cytoskeleton signaling. The ATP binding cassette subfamily G member 1 (ABCG1) transduces the ECM1a-integrin alpha X/beta 2 interactive signaling to facilitate the phosphorylation of AKT/FAK/Rho/cytoskeletal molecules and to confer cancer cell cisplatin resistance through up-regulation of the CD326-mediated cell stemness. On the contrary, the non-secretory ECM1b isoform binds myosin and blocks its phosphorylation, impairing cytoskeleton-mediated signaling and tumo

ORGANISM(S): Homo sapiens (human)

SUBMITTER: Gong Yang 

PROVIDER: S-BIAD116 | bioimages |

REPOSITORIES: bioimages